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FLASH GENE
Symbol GIGYF2 contributors: mct/npt - updated : 24-10-2016
HGNC name GRB10 interacting GYF protein 2
HGNC id 11960
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
Nervousbrain    
Reproductivefemale systemovary   
 male systemtestis  highly
 male systemprostate   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GYF domain, conserved eukaryotic adaptor domain that recognize proline-rich sequences, interact with the GRB10 proline-rich region, and bind AGO2
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may acting cooperatively with GRB10 to regulate receptor signaling
  • EIF4E2-GIGYF2 are a cofactor in translational repression and mRNA decay by ZFP36
  • upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • linked to IGF-I receptors by the GRB10 adapter protein following IGF-I stimulation
  • GIGYF2 directly interacts with EIF4E2, and this interaction is required for stabilization of both proteins
  • AGO2 interacting with GIGYF2 through the GYF domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PARK11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    might contribute to the development of diabetes-associated cognitive disorder via negatively regulating IGF1R signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    down-regulation of GIGYF2 expression may provide a potential novel approach to treat diabetes-associated cognitive impairment caused by aberrant IGF1R signaling pathway
    ANIMAL & CELL MODELS
  • Heterozygous Gigyf2 +/- mice exhibits histopathological evidence of neurodegeneration such as motor dysfunction