Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GGCX | contributors: mlc - updated : 14-11-2007 |
HGNC name | gamma-glutamyl carboxylase |
HGNC id | 4247 |
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Corresponding disease |
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Location | 2p12 Physical location : 85.776.192 - 85.788.657 | ||
Synonym name | vitamin K-dependent gamma-carboxylase | ||
Synonym symbol(s) | VKCFD1, FLJ26629 | ||
EC.number | 6.4.-.- |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | head to head |
STRUCTURE | 12.00 kb 15 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
| three transmembrane domains near its amino terminus |
HOMOLOGY |
Homologene |
FAMILY |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | GGCXD |
Susceptibility |
Variant & Polymorphism
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Candidate gene | for the investigation of inter-individual differences in the warfarin maintenance dose requirement | ||
Marker
Therapy target
| should serve as a useful resource for further pharmacogenetic studies for various drugs in whose pharmacological pathway GGCX may be involved |
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ANIMAL & CELL MODELS |