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FLASH GENE
Symbol GGCX contributors: mlc - updated : 14-11-2007
HGNC name gamma-glutamyl carboxylase
HGNC id 4247
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3236 - 758 - Kinoshita (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 mouthtongue  highly
Reproductivefemale systemplacenta  highly
 male systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three transmembrane domains near its amino terminus
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • gamma-glutamyl carboxylase, activating vitamin K-dependent proteins
  • plays an important role in blood coagulation through post-translational carboxylation of vitamin K-dependent blood-clotting proteins
  • involved in vitamin K-dependent carboxylation of multiple amino- terminal glutamate residues in various proteins
  • converting glutamate residues to gamma-carboxyglutamate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GGCXD
    Susceptibility
    Variant & Polymorphism
    Candidate gene for the investigation of inter-individual differences in the warfarin maintenance dose requirement
    Marker
    Therapy target should serve as a useful resource for further pharmacogenetic studies for various drugs in whose pharmacological pathway GGCX may be involved
    ANIMAL & CELL MODELS