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FLASH GENE
Symbol GFRA1 contributors: mct/npt - updated : 07-06-2008
HGNC name GDNF family receptor alpha 1
HGNC id 4243
Location 10q26      Physical location : 117.816.443 - 118.033.126
Synonym name
  • cell line-derived neurotrophic factor (GDNF) receptor alpha
  • RET ligand 1
  • glial cell line-derived neurotrophic factor receptor alpha
  • PI-linked cell-surface accessory protein
  • Synonym symbol(s) GDFNRA, RETL1, TRNR1, GFR-ALPHA-1, MGC23045
    DNA
    TYPE functioning gene
    STRUCTURE 210.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D10S1269 - [D10S1773 - D10S187 ] - D10S221 - qter
    Authors Angrist (98)
    Text [GFRA1 ]
    Physical map
    NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein GFRA1 10q26 GDNF family receptor alpha 1 MGC35062 10q26.11-q26.12 Similar to RIKEN cDNA 1700011F14 gene LOC119548 10q26.12 hypothetical protein LOC119548 PNLIP 10q24-q26 pancreatic lipase PNLIPRP1 10q26.12 pancreatic lipase-related protein 1 PNLIPRP2 10q26.12 pancreatic lipase-related protein 2 MGC33547 10q26.12 hypothetical protein MGC33547 HSPA12A  heat shock 70kDa protein 12A LOC387712 10 similar to RIKEN cDNA 6430537H07 gene KIAA1598 10q26.12 KIAA1598 protein LOC387713 10 similar to ventral anterior homeobox 1 TRIK 10q26.12 TWIK-related spinal cord K+ channe SLC18A2 10q25 solute carrier family 18 (vesicular monoamine), member 2 LOC118987 10q26.12 hypothetical protein LOC118987 LOC387714 10 LOC387714 EMX2 10q26.1 empty spiracles homolog 2 (Drosophila) Rab11-FIP2 10q26.12 KIAA0941 protein C10orf5 10q26.12 chromosome 10 open reading frame 5 FLJ13188 10q26.12 hypothetical protein FLJ13188
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2919 51 465 - Esseghir (2007)
    - - 2592 - 460 - Esseghir (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrineparathyroid   highly
    Reproductivefemale systembreastmammary gland highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    digestifintestine
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cysteine residues linked by hinge regions
  • secondary structure nine alpha helices with two central beta strands
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to GFRA2,GFRA3,GFRA4
    Homologene
    FAMILY
  • GDNFR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosyl phosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol-anchored cell surface coreceptor for GDNF, involved in RET signaling pathway
  • receptor for neurturin
  • mediating the action of Ret protein receptor tyrosine kinase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GDNF
  • NTRN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of estrogen receptor-positive breast tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS