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FLASH GENE
Symbol GFRA1 contributors: mct/npt - updated : 07-06-2008
HGNC name GDNF family receptor alpha 1
HGNC id 4243
Location 10q26      Physical location : 117.816.443 - 118.033.126
Synonym name
  • cell line-derived neurotrophic factor (GDNF) receptor alpha
  • RET ligand 1
  • glial cell line-derived neurotrophic factor receptor alpha
  • PI-linked cell-surface accessory protein
    • Synonym symbol(s) GDFNRA, RETL1, TRNR1, GFR-ALPHA-1, MGC23045
    DNA
    TYPE functioning gene
    STRUCTURE 210.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D10S1269 - [D10S1773 - D10S187 ] - D10S221 - qter
    Authors Angrist (98)
    Text [GFRA1 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2919 51 465 - Esseghir (2007)
    - - 2592 - 460 - Esseghir (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrineparathyroid   highly
    Reproductivefemale systembreastmammary gland highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    digestifintestine
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cysteine residues linked by hinge regions
    • secondary structure nine alpha helices with two central beta strands
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to GFRA2,GFRA3,GFRA4
    Homologene
    FAMILY
  • GDNFR family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosyl phosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol-anchored cell surface coreceptor for GDNF, involved in RET signaling pathway
  • receptor for neurturin
  • mediating the action of Ret protein receptor tyrosine kinase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GDNF
  • NTRN
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of estrogen receptor-positive breast tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS