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FLASH GENE
Symbol GFRA1 contributors: mct/npt - updated : 07-06-2008
HGNC name GDNF family receptor alpha 1
HGNC id 4243
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine residues linked by hinge regions
  • secondary structure nine alpha helices with two central beta strands
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to GFRA2,GFRA3,GFRA4
    Homologene
    FAMILY
  • GDNFR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosyl phosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol-anchored cell surface coreceptor for GDNF, involved in RET signaling pathway
  • receptor for neurturin
  • mediating the action of Ret protein receptor tyrosine kinase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GDNF
  • NTRN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of estrogen receptor-positive breast tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS