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FLASH GENE
Symbol GAS1 contributors: mct - updated : 19-03-2012
HGNC name growth arrest-specific 1
HGNC id 4165
Location 9q21.33      Physical location : 89.559.278 - 89.562.104
Synonym symbol(s) GAS-1
DNA
TYPE functioning gene
STRUCTURE 2.83 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC389764 9 similar to kinesin family member 27 LOC389765 9 similar to kinesin family member 27 LOC138198 9q22.1 similar to prohibitin FLJ21613 9q22.1 corneal wound healing-related protein GOLPH2 9p24.1-q32 golgi phosphoprotein 2 LOC389766 9 similar to RIKEN cDNA 4921517D22 HBLD2 9q22.1 HESB like domain containing 2 ZCCHC6 9q21 zinc finger, CCHC domain containing 6 LOC392358 9 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) GAS1 9q21.3-q22.1 growth arrest-specific 1 LOC157956 9q22.1 cell division cycle 20 pseudogene LOC392359 9 similar to transactivator HSM-1 DAPK1 9q34.1 death-associated protein kinase 1 CTSL 9q21-q22 cathepsin L LOC392360 9 similar to Eukaryotic translation initiation factor 3 subunit 1 (eIF-3 alpha) (eIF3 p35) (eIF3j) LOC392361 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392362 9 similar to fructose-1,6-bisphosphatase 2; fructose-1,6-bisphosphatase isozyme 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase; FBPase; muscle fructose-bisphosphatase; hexosediphosphatase LOC392363 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392364 9 similar to chromosome 15 open reading frame 2 FLJ35866 LOC286235 9q22.2 hypothetical protein LOC286235 CCRK 9q22.2 cell cycle related kinase LOC158104 9q22.2 similar to 40S ribosomal protein S10 LOC389767 9 LOC389767 DKFZP434M131 9q22.1 DKFZP434M131 protein LOC389768 9 similar to potassium channel tetramerisation domain containing 1; chromosome 18 open reading frame 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2844 35.6 345 - 2008 18981472
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung   predominantly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane protein with extracellular cysteines
  • a RGD motif
  • HOMOLOGY
    interspecies homolog to murine Gas1
    Homologene
    FAMILY
    CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GPI-linked protein involved in growth suppression (blocking entry to S phase)
  • cell cycle inhibitor of the G(0) to S phase transition
  • having a role in transcriptional silencing, distinct from its role in cell wall biogenesis
  • novel APP-interacting protein involved in the control of APP maturation and processing
  • GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube
  • promotes myogenic differentiation through regulation of cell cycle arrest and is critical to activate MAPK14, most likely via association with CDON/Cadherin multiprotein complexes
  • GAS1 and CDON are coexpressed in muscle cells and form a complex in differentiating myoblasts
  • cell membrane receptor and positive regulator of SHH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Hedgehog (HH) growth factor is a ligand for GAS1
  • negatively regulated APP intracellular trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    five novel missense sequence variants, that can impair its physical interaction with SHH, present in holoprosencephaly patients
    tumoral     --low  
    correlates with recurrence in stage II and III colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS