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FLASH GENE

Symbol

GAS1

contributors: mct - updated : 19-03-2012

HGNC name	growth arrest-specific 1
HGNC id	4165

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q21.33      Physical location : 89.559.278 - 89.562.104
Synonym symbol(s)	GAS-1

DNA

TYPE	functioning gene
STRUCTURE	2.83 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002048 1 - 2844 NP_002039 35.6 345 - 2008 18981472

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory lung       predominantly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Muscular myoblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane protein with extracellular cysteines
	a RGD motif

HOMOLOGY

interspecies

homolog to murine Gas1

Homologene

FAMILY

CATEGORY

regulatory , signaling growth factor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	GPI-linked protein involved in growth suppression (blocking entry to S phase)
	cell cycle inhibitor of the G(0) to S phase transition
	having a role in transcriptional silencing, distinct from its role in cell wall biogenesis
	novel APP-interacting protein involved in the control of APP maturation and processing
	GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube
	promotes myogenic differentiation through regulation of cell cycle arrest and is critical to activate MAPK14, most likely via association with CDON/Cadherin multiprotein complexes
	GAS1 and CDON are coexpressed in muscle cells and form a complex in differentiating myoblasts
	cell membrane receptor and positive regulator of SHH

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	Hedgehog (HH) growth factor is a ligand for GAS1
	negatively regulated APP intracellular trafficking

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       five novel missense sequence variants, that can impair its physical interaction with SHH, present in holoprosencephaly patients tumoral     --low   correlates with recurrence in stage II and III colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS