Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GAS1 contributors: mct - updated : 19-03-2012
HGNC name growth arrest-specific 1
HGNC id 4165
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane protein with extracellular cysteines
  • a RGD motif
  • HOMOLOGY
    interspecies homolog to murine Gas1
    Homologene
    FAMILY
    CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GPI-linked protein involved in growth suppression (blocking entry to S phase)
  • cell cycle inhibitor of the G(0) to S phase transition
  • having a role in transcriptional silencing, distinct from its role in cell wall biogenesis
  • novel APP-interacting protein involved in the control of APP maturation and processing
  • GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube
  • promotes myogenic differentiation through regulation of cell cycle arrest and is critical to activate MAPK14, most likely via association with CDON/Cadherin multiprotein complexes
  • GAS1 and CDON are coexpressed in muscle cells and form a complex in differentiating myoblasts
  • cell membrane receptor and positive regulator of SHH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Hedgehog (HH) growth factor is a ligand for GAS1
  • negatively regulated APP intracellular trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    five novel missense sequence variants, that can impair its physical interaction with SHH, present in holoprosencephaly patients
    tumoral     --low  
    correlates with recurrence in stage II and III colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS