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FLASH GENE
Symbol GALE contributors: mct/npt - updated : 15-05-2013
HGNC name UDP-galactose-4-epimerase
HGNC id 4116
Corresponding disease
GALED galactosemia, type III
Location 1p36.11      Physical location : 24.122.088 - 24.127.294
Synonym name
  • galactowaldenase
  • galactose-4-epimerase, UDP-
  • short chain dehydrogenase/reductase family 1E, member 1
    • Synonym symbol(s) SDR1E1, FLJ97302, FLJ95174, RP5-886K2.6
    EC.number 5.1.3.2
    DNA
    TYPE functioning gene
    STRUCTURE 3.97 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text all transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1647 - 348 - Daude (1995)
    12 - 1585 - 348 - Daude (1995)
    11 - 1626 - 348 - Daude (1995)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila cg-12030
    Homologene
    FAMILY
  • NAD dependent epimerase
  • sugar epimerase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • bifunctional enzyme catalysing epimerization of UDP glucose and of UDP-N acetylglucosamine
  • catalyses the interconversion of UDP-glucose and UDP-galactose (Timson 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • NAD
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GALED
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS