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Symbol FZR1 contributors: mct - updated : 16-02-2013
HGNC name fizzy/cell division cycle 20 related 1 (Drosophila)
HGNC id 24824
Location 19p13.3      Physical location : 3.506.294 - 3.536.755
Synonym name
  • fizzy related protein
  • frog fizzy related protein
  • Synonym symbol(s) HGNC24824, FZR, FZR2, HCDH, HCDH1, KIAA1242, CDH1
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven WD repeats (Trp-Asp domains)
    HOMOLOGY
    interspecies homolog to yeast cdh1/hct1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • essential for cyclosome activity in G1
  • activating the anaphase promoting complex (APC) by promoting APC cyclin ubiquitination activity
  • targeting specific substrates lacking the D box in G1 (such as polo-like kinase for ubiquitination)
  • APC/C coactivator protein involved in ubiquitination and down-regulating the stability of TRIB3 protein
  • CELLULAR PROCESS cell cycle
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • substrate-specific APC/C activators
  • controlling axonal growth and the patterning of mammalian brain
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APC/C complex
  • mediating its own degradation
  • MAK associates with FZR1, and phosphorylates FZR1 at sites phosphorylated by cyclin-dependent kinases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS