| 1 | DEE109, FZR1
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| De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies.
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| Manivannan SN, Roovers J, Smal N, Myers CT, Turkdogan D, Roelens F, Kanca O, Chung HL, Scholz T, Hermann K, Bierhals T, Caglayan HS, Stamberger H; MAE Working Group of EuroEPINOMICS RES Consortium; Mefford H, de Jonghe P, Yamamoto S, Weckhuysen S, Bellen HJ.
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| Brain Jun 3;145(5):1684-1697. doi: 10.1093/brain/awab409. 2022
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| 2 | FZR1, IDH2
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| APC/C CDH1 ubiquitinates IDH2 contributing to ROS increase in mitosis.
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| Lambhate S, Bhattacharjee D, Jain N.
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| Cell Signal. Oct;86:110087. doi: 10.1016/j.cellsig.2021.110087. Epub 2021 Jul 13. 2021
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| 3 | AURKA, FZR1
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| AURKA destruction is decoupled from its activity at mitotic exit but is essential to suppress interphase activity.
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| Abdelbaki A, Akman HB, Poteau M, Grant R, Gavet O, Guarguaglini G, Lindon C.
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| J Cell Sci. Jun 16;133(12):jcs243071. doi: 10.1242/jcs.243071 2020
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| 4 | FOXM1, FZR1
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| A Cdh1-FoxM1-Apc axis controls muscle development and regeneration.
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| Chen Z, Li L, Xu S, Liu Z, Zhou C, Li Z, Liu Y, Wu W, Huang Y, Kuang M, Fan S, Li H, Li X, Song G, Wu WS, Chen J, Hou Y.
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| Cell Death Dis. Mar 9;11(3):180. doi: 10.1038/s41419-020-2375-6 2020
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| 5 | DEE109, FZR1
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| A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy.
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| Rodríguez C, Sánchez-Morán I, Álvarez S, Tirado P, Fernández-Mayoralas DM, Calleja-Pérez B, Almeida Á, Fernández-Jaén A.
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| J Neurochem. Oct;151(1):103-115. doi: 10.1111/jnc.14828. Epub 2019 Aug 22. 2019
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| 6 | FZR1, SRC
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| Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. 2019 PMID:
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| Han T, Jiang S, Zheng H, Yin Q, Xie M, Little MR, Yin X, Chen M, Song SJ, Beg AA, Pandolfi PP, Wan L.
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| Nat Commun. Aug 16;10(1):3716. doi: 10.1038/s41467-019-11618-7. 2019
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| 7 | BRAF, FZR1
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| The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
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| Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W.
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| Cancer Discov. Apr;7(4):424-441. doi: 10.1158/2159-8290.CD-16-0647. Epub 2017 Feb 7. 2017
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| 8 | E2F1, FZR1
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| CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.
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| Singh RK, Dagnino L.
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| Oncotarget Jan 17;8(3):4977-4993. doi: 10.18632/oncotarget.13636 2017
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| 9 | FZR1
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| The APC/C activator FZR1 is essential for meiotic prophase I in mice.
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| Holt JE, Pye V, Boon E, Stewart JL, García-Higuera I, Moreno S, Rodríguez R, Jones KT, McLaughlin EA.
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| Development. Mar;141(6):1354-65. doi: 10.1242/dev.104828. Epub 2014 Feb 19. 2014
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| 10 | FZR1, MAK
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| Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.
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| Wang LY, Kung HJ.
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| Oncogene 31(24):2907-18. doi: 10.1038/onc.2011.464. Epub 2011 Oct 10.
2012
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| 11 | FZR1, TRIB3
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| Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.
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| Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
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| Biochem Biophys Res Commun 392(3):289-94. doi: 10.1016/j.bbrc.2009.12.175. Epub 2010 Jan 11.
2010
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| 12 | ANAPC1, FZR1, NEDD9
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| The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome.
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| Pugacheva EN, Golemis E.A
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| Nat Cell Biol 7(10):937-46. Epub 2005 Sep 25. 2005
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| 13 | FZR1
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| Mammalian Cdh1/Fzr mediates its own degradation.
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| Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, Lebendiker M, Brandeis M.
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| EMBO J 23(7):1619-26. Epub 2004 Mar 18. 2004
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| 14 | ANAPC1, ANAPC2, ANAPC11, FZR1
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| Cdh1-APC controls axonal growth and patterning in the mammalian brain.
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| Konishi Y, Stegmuller J, Matsuda T, Bonni S, Bonni A.
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| Science 303(5660):1026-30. Epub 2004 Jan 08. 2004
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| 15 | FZR1
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| The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels.
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| Inbal N, Listovsky T, Brandeis M.
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| FEBS Lett 463(3):350-4. 1999
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| 16 | AARS2, ADAMTSL3, AHRR, AMIGO1, ANKFY1, ARHGAP31, ARID1A, ARID1B, ASAP1, ASB1, BACE1, BIRC6, BRPF3, C14orf118, CASKIN2, CCPG1, CD2BP2, CNOT6, COG6, CPAMD8, DCDC2, DLG3, ERBIN, ERGIC1, FAM190B, FAM63B, FBXO40, FILIP1, FSTL5, FZR1, GALNTL1, GATAD2B, GDA, GMEB2, GNPTAB, GRID1, GRIPAP1, HECTD1, HEG1, HHATL, INTU, IPO9, ISY1, KCNH3, KIAA1143, KIAA1191, KIAA1217, KIAA1274, LCHN, LMBR1L, LRFN2, LRRC47, MACF1, MAP7D1, MIER2, MTA3, MYO5B, MYOF, MYORG, NDFIP2, NDRG2, NELFB, NLGN4X, NLN, OGDHL, PAIP2B, PAK7, PECR, PLEKHG1, PLEKHH1, PNKD, PNMAL2, PPP1R9A, PRDM10, REXO1, RIMKLB, RNF150, SGPL1, SHROOM4, SLC39A10, SLC45A4, SRGAP2, STK36, SULF2, TBC1D24, TLE4, TMCC3, TPCN1, TRMT6, TTC7A, TTC7B, USP31, ZBTB21, ZBTB47, ZC4H2, ZNF490, ZNF644, ZNF777
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| Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
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| Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O.
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| DNA Res 6(5):329-36. 1999
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| 17 | CDC20, FZR1
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| Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.
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| Fang G, Yu H, Kirschner MW.
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| Mol Cell 2(2):163-71. 1998
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