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Symbol FYN contributors: mct/npt/pgu - updated : 17-08-2016
HGNC name FYN oncogene related to SRC, FGR, YES
HGNC id 4037
Location 6q21      Physical location : 111.982.486 - 112.194.627
Synonym name
  • OKT3-induced calcium influx regulator
  • c-syn protooncogene
  • protein-tyrosine kinase fyn
  • src-like kinase
  • tyrosine kinase p59fyn(T)
  • proto-oncogene tyrosine-protein kinase Fyn
  • Synonym symbol(s) SYR, SLK, SYN, FYnt, MGC45350
    TYPE functioning gene
    STRUCTURE 212.14 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    DDO 6q22.1 D-aspartate oxidase SLC22A16 6q22.1 solute carrier family 22 (organic cation transporter), member 16 CDK11 6q22.1 cyclin-dependent kinase (CDC2-like) 11 LOC391959 6 similar to calponin 2; Calonin 2 AMD1 6q21-q22 adenosylmethionine decarboxylase 1 LOC221269 6q22.1 similar to 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) C6orf51 6q21 chromosome 6 open reading frame 51 BXDC1 6q22.1 brix domain containing 1 LOC221270 6q22.1 similar to glutathione transferase M2 SLC16A10 6q21-q22 solute carrier family 16 (monocarboxylic acid transporters), member 10 KIAA1919 6q22 KIAA1919 REV3L 6q21 REV3-like, catalytic subunit of DNA polymerase zeta (yeast) LOC51212 6q22.1 diferentiation-related protein dif13 C6orf4 6q21 chromosome 6 open reading frame 4 FYN 6q21 FYN oncogene related to SRC, FGR, YES WISP3 6q22-q23 WNT1 inducible signaling pathway protein 3 TUBE1 6q12 tubulin, epsilon 1 LAMA4 6q21 laminin, alpha 4 LOC345882 6q22.1 similar to Pin2-interacting protein X1 (TRF1-interacting protein 1) (Liver-related putative tumor suppressor) (67-11-3 protein) LOC221278 6q22.1 similar to ret finger protein-like 1 LOC391960 6 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC345884 6q22.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC391961 6 similar to fem-1 homolog a (C.elegans) LOC389424 6 similar to Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2650 60 537 - 2010 19733625
  • a 14 exons variant
  • lacking exons 4 and 11
  • encoding for the longest product
  • 11 splicing 2073 60 534 - 2010 19733625
  • an 11 exons variant
  • lacking exons 1, 2, 3 and 4
  • 11 splicing 2000 54.4 482 - 2010 19733625
  • a 11 exons variant
  • lacking exons 1, 2, 3, 10 and 11
  • encoding for the shortest product
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   moderately
    Endocrinethyroid   highly
    Lymphoid/Immunespleen   highly
     thymus   moderately
    Nervousbrain   moderately
     nerve   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period embryo
    Text embryonic tissue
  • a Src homolgy 2, a Src homology 3 domains
  • a K homology (KH) motif bound to a QUA2 motif (RNA binding)
  • a proteine kinase catalytic domain
    interspecies homolog to rattus Fyn (99.63 pc)
    homolog to murine Fyn (94.19 pc)
  • Src-family tyrosine kinases
  • Tyr protein kinase family
  • SRC subfamily (signal transduction)
  • STAR (signal transduction and activator of RNA) family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • non receptor tyrosine kinase, involved in T cell signaling regulation
  • also involved in protocadherin signaling
  • monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
  • implicated in both brain development and adult brain function
  • in mast cell degranulation in interacting with both cytosolic and structural proteins
  • involved in mast cell degranulation in interacting with both cytosolic and structural proteins
  • may play an important role in HTR6- mediated signaling pathways in the central nervous system
  • involved in tyrosine phosphorylation of KIRREL (results in significantly increased KIRREL and TJP1 binding, suggesting a critical role for KIRREL tyrosine phosphorylation in reorganizing the KIRREL-TJP1 complex)
  • mediates chronic myelogenous leukemia cell proliferation
  • in part through its effects on DAB1, regulates the phosphorylation, trafficking, and processing of APP and LRP8
  • playing a role in exit from meiotic and mitotic metaphases and required for regulation of microtubules polymerization and spindle stabilization
  • play an essential role in signaling events that implicate spindle assembly checkpoint pathway and hence in regulating the exit from metaphase in oocytes and zygote
  • plays a key role in oligodendrocyte differentiation and myelination in the central nervous system
  • FYN cooperates with oncogenic FLT3-ITD in cellular transformation by selective activation of the STAT5 pathway
  • MAGI2 and FYN protect DDN from NEDD4L-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI2 in podocytes results in glomerulosclerosis
  • CELLULAR PROCESS cell life, proliferation/growth
    signaling signal transduction
    a component
    small molecule metal binding, nucleotide,
  • ATP
  • Mn2+
  • protein
  • the cytoplasmic tail of protocadherins
  • ADD2 (colocalizing under plasma membranes)
  • binding to vimentin and pyruvate kinase
  • complexed with staurosporine
  • ARHGAP33 is a novel FYN substrate
  • interacting with brain-specific PTPRT (PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase FYN)
  • PTPRA is an important positive regulator of FYN activation and signaling that is required for the differentiation of oligodendrocyte progenitor cells (OPCs)
  • interaction with FYB, a FYN adapter protein expressed in podocytes, and TMEM47 possibly through FYB, may regulate FYN activity
  • SLIT2 regulates the dispersal of oligodendrocyte precursor cells through FYN and RHOA signaling
  • NCK1 directly modulates NPHS1 phosphorylation through formation of a signaling complex with the Src family kinase FYN
  • functional interaction between FYN, AGAP2, and STAT5A in mediating adipogenesis
  • UNC119 plays a key role in the FYN signal transduction pathway, which regulates the completion of cytokinesis via RAB11A
  • dynamic interaction between CAMK2D2 and FYN in VSM (Vascular smooth muscle) cells, indicating a mechanism by which CAMK2D2 and FYN may coordinately regulate VSM cell motility
  • SH2D1a plays an essential role in collagen-induced arthritis (CIA) because of FYN-independent and FYN-dependent effects on follicular T helper (TFH) cells and, possibly, other T cell types
  • DDN is phosphorylated by FYN and dephosphorylated by PTPN1, and FYN-induced phosphorylation prevents NEDD4L-mediated ubiquitination of dendrin
  • FYN has likely a regulatory role in NOS2 expression in astrocytes during neuroinflammatory responses
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activated in clear cell renal carcinoma with good outcome
    tumoral     --over  
    in chronic myelogenous leukemia blast crisis compared with chronic phase
    Variant & Polymorphism
    Candidate gene
    Therapy target therapies targeting Fyn expression for chronic myelogenous leukemia