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FLASH GENE

Symbol

FSD2

contributors: mct - updated : 04-10-2023

HGNC name	fibronectin type III and SPRY domain containing 2
HGNC id	18024

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q25.2      Physical location : 83.428.023 - 83.474.806
Synonym name	SPRY domain containing 1
	minispryn
Synonym symbol(s)	RP11-127F21, SPRYD1

DNA

TYPE	functioning gene
STRUCTURE	50.71 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001281806 12 - 6283 NP_001268735 - 704 - 2017 28740084 NM_001281805 13 - 6400 NP_001268734 - 704 - 2017 28740084 NM_001007122 13 - 6418 NP_001007123 - 749 - 2017 28740084

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive intestine small intestine       Lymphoid/Immune lymph node         Reproductive female system uterus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac myocardium   Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Fsd2 (83.0pc)

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
	intracellular,nuclear envelope
text	CMYA5, FSD2 and RYR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SPEG interacts with myospryn complex proteins (CMYA5, FSD2, RYR1), and its deficiency results in myospryn complex abnormalities
	SPEG is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase D (ESD), CMYA5, and Fibronectin Type III and FSD2 in cardiac and skeletal muscle

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS