Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FSD2 contributors: mct - updated : 04-10-2023
HGNC name fibronectin type III and SPRY domain containing 2
HGNC id 18024
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Fsd2 (83.0pc)
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
intracellular,nuclear envelope
text
  • CMYA5, FSD2 and RYR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes
    • basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPEG interacts with myospryn complex proteins (CMYA5, FSD2, RYR1), and its deficiency results in myospryn complex abnormalities
  • SPEG is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase D (ESD), CMYA5, and Fibronectin Type III and FSD2 in cardiac and skeletal muscle
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS