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FLASH GENE
Symbol FRK contributors: mct - updated : 04-01-2013
HGNC name fyn-related kinase
HGNC id 3955
Location 6q22.1      Physical location : 116.262.692 - 116.381.921
Synonym name
  • nuclear tyrosine protein kinase RAK
  • tyrosine-protein kinase FRK
  • PTK5 protein tyrosine kinase 5
    • Synonym symbol(s) GTK, RAK, PTK5
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 119.23 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2864 58 505 - 2009 19345329
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Endocrinepancreas     Homo sapiens
    Reproductivefemale systembreast    Homo sapiens
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Respiratoryepithelial cell
    cell lineage
    cell lines K-562, human leukemia cells
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G1, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SH2 and one SH3 domain
  • a tyrosine kinase domain
    • HOMOLOGY
    interspecies ortholog to murine Frk
    homolog to rattus frk
    Homologene
    FAMILY
  • small family of intracellular Src-related tyrosine kinases
  • Tyr protein kinase family
  • SRC subfamily
    • CATEGORY enzyme , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be functioning during G1 and S phase of the cell cycle and suppress growth
  • involved in TERT regulation
  • affects pancreatic beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions
  • acts as a bona fide tumor suppressor gene through the mechanism of regulating PTEN protein stability and function
  • both FRK and PTK6 have been implicated in the regulation of epithelial cell differentiation and apoptosis
  • has tumor suppressor functions in mammary gland cells
  • VEGFA and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced age-related macular degeneration
  • may play a protective role against the progression of glioma by suppressing cell migration and invasion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text intracellular signaling cascade
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • physically interacts with PTEN and phosphorylates PTEN on Tyr336
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ETV6 in t(6;12)(q21;p13)in acute myelogenous leukemia (fusion protein ETV6/FRK contributing to oncogenesis)
    Susceptibility to advanced age-related macular degeneration
    Variant & Polymorphism SNP
  • rs1999930 near FRK/COL10A1 associated with advanced age-related macular degeneration
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS