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FLASH GENE
Symbol FRK contributors: mct - updated : 04-01-2013
HGNC name fyn-related kinase
HGNC id 3955
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Endocrinepancreas     Homo sapiens
Reproductivefemale systembreast    Homo sapiens
Respiratoryrespiratory tractlarynx   
Urinarybladder    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Homo sapiens
Respiratoryepithelial cell
cell lineage
cell lines K-562, human leukemia cells
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH2 and one SH3 domain
  • a tyrosine kinase domain
  • HOMOLOGY
    interspecies ortholog to murine Frk
    homolog to rattus frk
    Homologene
    FAMILY
  • small family of intracellular Src-related tyrosine kinases
  • Tyr protein kinase family
  • SRC subfamily
  • CATEGORY enzyme , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be functioning during G1 and S phase of the cell cycle and suppress growth
  • involved in TERT regulation
  • affects pancreatic beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions
  • acts as a bona fide tumor suppressor gene through the mechanism of regulating PTEN protein stability and function
  • both FRK and PTK6 have been implicated in the regulation of epithelial cell differentiation and apoptosis
  • has tumor suppressor functions in mammary gland cells
  • VEGFA and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced age-related macular degeneration
  • may play a protective role against the progression of glioma by suppressing cell migration and invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text intracellular signaling cascade
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • physically interacts with PTEN and phosphorylates PTEN on Tyr336
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ETV6 in t(6;12)(q21;p13)in acute myelogenous leukemia (fusion protein ETV6/FRK contributing to oncogenesis)
    Susceptibility to advanced age-related macular degeneration
    Variant & Polymorphism SNP
  • rs1999930 near FRK/COL10A1 associated with advanced age-related macular degeneration
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS