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FLASH GENE
Symbol FOXQ1 contributors: mct - updated : 03-12-2011
HGNC name forkhead box Q1
HGNC id 20951
Location 6p25.3      Physical location : 1.312.674 - 1.314.992
Synonym name
  • winged helix/forkhead transcription factor
  • HNF-3/forkhead-like protein 1
  • Synonym symbol(s) HFH1
    DNA
    TYPE functioning gene
    STRUCTURE 2.32 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1 C6orf35 6q25.3 chromosome 6 open reading frame 35 LOC389357 6 LOC389357 DUSP22 6p24.3 dual specificity phosphatase 22 IRF4 6p25-p23 interferon regulatory factor 4 SEC5 LOC391990 6 similar to serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II HUS1B 6p25.3 HUS1 checkpoint homolog b (S. pombe) LOC340177 6q27 hypothetical LOC340177 LOC389452 6 LOC389452 LOC391991 6 similar to lysR-like transcriptional regulator LOC391992 6 similar to putative heavy metal transporter LOC391993 6 similar to F22G5.20 LOC391994 6 similar to Hypothetical protein FLJ30525 LOC221768 6p25.3 similar to ENSANGP00000010305 FOXQ1 6p25-p23 forkhead box Q1 LOC389358 6 LOC389358 FOXF2 6p25.3 forkhead box F2 LOC221766 6p25.3 hypothetical LOC221766 LOC389359 6 LOC389359 LOC389360 6 LOC389360 LOC389361 6 LOC389361 FOXC1 6p25 forkhead box C1 GMDS 6p25 GDP-mannose 4,6-dehydratase LOC285770 6p25.2 similar to FLJ00254 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2338 - 403 - 2001 11747606
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
     salivary gland    
     stomach    
    Respiratorylung    
     respiratory tracttrachea   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neuroblasts derived from procephalic region, ventral nervous system, thoracic sensory neurons and brain cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative transcriptional activation domain
  • one fork-head DNA-binding domain
  • HOMOLOGY
    interspecies ortholog to murine Foxq1
    Homologene
    FAMILY
  • member of the cancer-related FOX family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in development during embryogenesis
  • HOXC13 and FOXQ1 control medulla differentiation of the hair through a common regulatory pathway
  • potential functional roles, for epithelial plasticity
  • involved in regulation of transcription, DNA-dependent
  • critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells
  • FOXQ1-induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin (CDH1)
  • a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FOXF1 and FOXQ1 directly bind to distinct regions of MYOCD
  • directly bound to the SOX12 promoter and transactivated its expression, which contributed to SOX12 overexpression in human hepatocellular carcinoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS