Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FOXQ1 contributors: mct - updated : 03-12-2015
HGNC name forkhead box Q1
HGNC id 20951
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2338 - 403 - 2001 11747606
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary gland    
 stomach    
Respiratorylung    
 respiratory tracttrachea   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text neuroblasts derived from procephalic region, ventral nervous system, thoracic sensory neurons and brain cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two putative transcriptional activation domain
  • one fork-head DNA-binding domain
  • HOMOLOGY
    interspecies ortholog to murine Foxq1
    Homologene
    FAMILY
  • member of the cancer-related FOX family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in development during embryogenesis
  • HOXC13 and FOXQ1 control medulla differentiation of the hair through a common regulatory pathway
  • potential functional roles, for epithelial plasticity
  • involved in regulation of transcription, DNA-dependent
  • critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells
  • FOXQ1-induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin (CDH1)
  • a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer
  • FOXC1, GMDS, FOXF2, and FOXQ1 may represent loci for enhancer-driven changes in gene expression that could affect the developing embryo
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FOXF1 and FOXQ1 directly bind to distinct regions of MYOCD
  • directly bound to the SOX12 promoter and transactivated its expression, which contributed to SOX12 overexpression in human hepatocellular carcinoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS