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FLASH GENE
Symbol FLG2 contributors: mct/npt - updated : 19-03-2013
HGNC name filaggrin family member 2
HGNC id 33276
Location 1q21.3      Physical location : 152.321.213 - 152.332.482
Synonym name
  • ifapsoriasin
  • filaggrin 2
  • intermediate filament-associated and psoriasis-susceptibility protein
    • Synonym symbol(s) IFPS, FLG-2
    DNA
    TYPE functioning gene
    STRUCTURE 11.27 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 9170 248.1 2391 - 2009 19384417
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach     Homo sapiensAdult
    Lymphoid/Immunethymus     Homo sapiensAdult
     tonsils     Homo sapiensAdult
    Reproductivefemale systemplacenta    Homo sapiensAdult
    Skin/Tegumentskin     Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum spinosum  Homo sapiensAdult
    Epithelialbarrier liningepidermisstratum granulosum  Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • S100-fused protein family (SFTP)
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • histidine- and glutamine-rich protein, which shares common structural features with other SFTP members, in particular filaggrin (
  • FLG and FLG2 display a related structural organization, an identical pattern of expression and localization in epidermis, and proteolytic processing of a large precursor
  • may contribute to epidermal barrier function and its regulation differs, at least in parts, from that of filaggrin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAPN1 is essential for the proteolytic processing of FLG2 and the deimination accelerates this process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS