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FLASH GENE
Symbol FLG2 contributors: mct/npt - updated : 19-03-2013
HGNC name filaggrin family member 2
HGNC id 33276
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 9170 248.1 2391 - 2009 19384417
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach     Homo sapiensAdult
Lymphoid/Immunethymus     Homo sapiensAdult
 tonsils     Homo sapiensAdult
Reproductivefemale systemplacenta    Homo sapiensAdult
Skin/Tegumentskin     Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermisstratum spinosum  Homo sapiensAdult
Epithelialbarrier liningepidermisstratum granulosum  Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • S100-fused protein family (SFTP)
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • histidine- and glutamine-rich protein, which shares common structural features with other SFTP members, in particular filaggrin (
  • FLG and FLG2 display a related structural organization, an identical pattern of expression and localization in epidermis, and proteolytic processing of a large precursor
  • may contribute to epidermal barrier function and its regulation differs, at least in parts, from that of filaggrin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAPN1 is essential for the proteolytic processing of FLG2 and the deimination accelerates this process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS