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FLASH GENE

Symbol

FGG

contributors: - updated : 13-10-2007

HGNC name	fibrinogen, G gamma polypeptide
HGNC id	3694

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CAFG congenital afibrinogenemia TRDF thrombosis, recurrent, dysfibrinogenemic type (fibrinogen A, B or G defect)
Location	4q28      Physical location : 155.525.286 - 155.533.902

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	see FG@
STRUCTURE	8.00 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - FGG - FGA - FGB - qter
Authors	Aschbacher et al.(85)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed FGG-A - splicing 1559 49.5 437 - Chung/Rixon FGG-B - splicing 1665 51.5 453 - Chung/Rixon lacking exon 10

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol   spleen       moderately Cardiovascular heart       highly Digestive liver       predominantly Nervous brain       highly Respiratory lung       highly Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

physiological period

embryo, fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short N terminal region
	a coiled-coil region and the flanking disulfide ring
	a single N linked glycosylation site in the middle of the coiled-coil region
	a unique high-affinity, nonsubstrate binding site for thrombin, which seems critical for the expression of the antithrombin activity that develops during fibrin formation
	a C terminal apparently globular region with an extension missing in beta chain and participation in intermolecular cross-linking

conjugated

GlycoP

mono polymer

heteromer , hexamer

isoforms

Precursor

cleaved by thrombin to form fibrin and various cleavage products of fibrinogen and fibrin

HOMOLOGY

interspecies	ortholog to murine Fgg
	homolog to C.elegans C49C8.5

Homologene

FAMILY

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	plasma

basic FUNCTION	playing a role in blood clots and other responses to injury (fibrin)
	regulating cell adhesion and spreading (various cleavage products of fibrinogen and fibrin)
	displaying vasoconstrictor and chemotactic activities (various cleavage products of fibrinogen and fibrin)
	being mitogens for several cell types (various cleavage products of fibrinogen and fibrin)
	involved in regulation of blood pressure
	acting as a cofactor in platelet aggregation
	yielding monomers that polymerize into fibrin

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

text	positive regulation of cell proliferation

PATHWAY

metabolism

signaling

a component

fibrinogen, dimeric protein consisting of six chains (alpha 2, beta 2, gamma 2) held together by disulfide bonds

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TRDF , CAFG

related resource

A Database For Human Fibrinogen Variants

Susceptibility

to deep venous thrombosis

Variant & Polymorphism SNP	FGG-H2 homozygosity associated with risk of deep venous thrombosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS