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FLASH GENE
Symbol FGG contributors: - updated : 13-10-2007
HGNC name fibrinogen, G gamma polypeptide
HGNC id 3694
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1559 49.5 437 - Chung/Rixon
- splicing 1665 51.5 453 - Chung/Rixon
lacking exon 10
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
 spleen   moderately
Cardiovascularheart   highly
Digestiveliver   predominantly
Nervousbrain   highly
Respiratorylung   highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion plasma
at STAGE
physiological period embryo, fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N terminal region
  • a coiled-coil region and the flanking disulfide ring
  • a single N linked glycosylation site in the middle of the coiled-coil region
  • a unique high-affinity, nonsubstrate binding site for thrombin, which seems critical for the expression of the antithrombin activity that develops during fibrin formation
  • a C terminal apparently globular region with an extension missing in beta chain and participation in intermolecular cross-linking
  • conjugated GlycoP
    mono polymer heteromer , hexamer
    isoforms Precursor cleaved by thrombin to form fibrin and various cleavage products of fibrinogen and fibrin
    HOMOLOGY
    interspecies ortholog to murine Fgg
    homolog to C.elegans C49C8.5
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text plasma
    basic FUNCTION
  • playing a role in blood clots and other responses to injury (fibrin)
  • regulating cell adhesion and spreading (various cleavage products of fibrinogen and fibrin)
  • displaying vasoconstrictor and chemotactic activities (various cleavage products of fibrinogen and fibrin)
  • being mitogens for several cell types (various cleavage products of fibrinogen and fibrin)
  • involved in regulation of blood pressure
  • acting as a cofactor in platelet aggregation
  • yielding monomers that polymerize into fibrin
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component fibrinogen, dimeric protein consisting of six chains (alpha 2, beta 2, gamma 2) held together by disulfide bonds
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TRDF , CAFG
    related resource A Database For Human Fibrinogen Variants
    Susceptibility to deep venous thrombosis
    Variant & Polymorphism SNP FGG-H2 homozygosity associated with risk of deep venous thrombosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS