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FLASH GENE
Symbol FGF4 contributors: mct/npt/pgu - updated : 15-09-2009
HGNC name fibroblast growth factor 4
HGNC id 3682
Corresponding disease
DUP11QP chromosome 11q proximal duplication
Location 11q13.3      Physical location : 69.587.796 - 69.590.171
Synonym name
  • human stomach cancer, transforming factor from FGF-related oncogene
  • heparin secretory transforming protein 1
  • kaposi sarcoma oncogene
  • transforming protein KS3
  • oncogene HST
  • Synonym symbol(s) HSTF1, HBGF-4, HST, HST-1, K-FGF, KFGF, KS3
    DNA
    TYPE functioning gene
    STRUCTURE 2.37 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see PYGM PYGM
    Physical map
    ALDH3B1 11q13 aldehyde dehydrogenase 3 family, member B1 NDUFS8 11q13 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) TCIRG1 11q13.4-q13.5 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3 CHK 11q13.1 choline kinase CGI-85 11q13 choline kinase C11orf24 11q13 chromosome 11 open reading frame 24 LRP5 11q13 low density lipoprotein receptor-related protein 5 C11orf23 11q13 chromosome 11 open reading frame 23 GAL 11q13.3-q13.5 galanin MTL5 11q13.2-q13.3 metallothionein-like 5, testis-specific (tesmin) CPT1A 11q13.1-q13.2 carnitine palmitoyltransferase 1A (liver) MRPL21 11q13.1 mitochondrial ribosomal protein L21 IGHMBP2 11q13.2-q13.4 immunoglobulin mu binding protein 2 MRGD 11 mas-related G protein-coupled MRGD MGC21621 11q13.1 G protein-coupled receptor MrgF TPCN2 11q13.1 two pore segment channel 2 LOC338694 11q13.2 hypothetical protein LOC338694 MYEOV 11q13.1 myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas) LOC390218 11 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) LOC220061 11q13.2 similar to proline rich antigen 2 CCND1 11q13.3 cyclin D1 (PRAD1: parathyroid adenomatosis 1) ORAOV1 11q13 oral cancer overexpressed 1 FGF19 11q13.1 fibroblast growth factor 19 FGF4 11q13.3 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) FGF3 11q13.3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog) ORAOV2 11q13.2 oral cancer overexpressed 2 FADD 11q13.3 Fas (TNFRSF6)-associated via death domain PPFIA1 11q13.3-q13.5 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 EMS1 11q13.3 ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate) SHANK2 11q11 SH3 and multiple ankyrin repeat domains 2 LOC220070 11q13.2 hypothetical protein BC004224 LOC341140 11q13.2 similar to Actin, alpha 1, skeletal muscle DHCR7 11q13.2-q13.5 7-dehydrocholesterol reductase NADSYN1 11q13.2 NAD synthetase 1 LOC57830 11q13.2 UHS KerB KRN1 11q13.5 keratin, cuticle, ultrahigh sulphur 1 LOC390219 11 LOC390219 OR7E3P 11q13 olfactory receptor, family 7, subfamily E, member 3 pseudogene LOC255620 11q13.2 hypothetical gene supported by NM_030930; AY007125
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1220 - 206 embryonic stem cells, early differentiated cells 2008 18192227
    - splicing 556 - - embryonic stem cells, early differentiated cells and continues to be expressed after cell differentiation 2008 18192227
  • also known as FGF4si
  • codes for the N-terminal half of FGF4
  • antagonist of FGF4, shutting down FGF4-induced Erk1/2 phosphorylation
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text ectoderm under SHH control
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to HST oncogene
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF4 subfamily
  • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • fibroblast growth factor 4, basic, involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression
  • controlling limb development at the proximodistal axis
  • could promote both proliferation and differentiation of the neural progenitor cells
  • has an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain
  • having a growth-promoting role in embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at later stages of development
  • FGF4 and FGF8 are the principal FGFs required for both axis extension and limb bud outgrowth
  • FGF4 and FGF8 action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM (presomitic mesoderm) progenitor tissue
  • FGF4 and FGF8 signaling acts as the sole mediator of wavefront activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stimulating MAP3K4 (requirement of FGF4-stimulated MAP3K4 activation of JNK for maintenance of a tissue stem cell)
  • FGF4 and FGF8 are the critical ligands for FGF signaling in the presomitic mesoderm
  • cell & other
    REGULATION
    Other ectoderm under SHH control
    ASSOCIATED DISORDERS
    corresponding disease(s) DUP11QP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS