basic FUNCTION
| fibroblast growth factor 4, basic, involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression |
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controlling limb development at the proximodistal axis |
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could promote both proliferation and differentiation of the neural progenitor cells |
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has an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain |
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having a growth-promoting role in embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at later stages of development |
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FGF4 and FGF8 are the principal FGFs required for both axis extension and limb bud outgrowth |
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FGF4 and FGF8 action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM (presomitic mesoderm) progenitor tissue |
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FGF4 and FGF8 signaling acts as the sole mediator of wavefront activity |
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role of FGF4 and MNDA in pluripotent cell responses to genotoxicity |