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FLASH GENE
Symbol FGF4 contributors: mct/npt/pgu - updated : 22-02-2017
HGNC name fibroblast growth factor 4
HGNC id 3682
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to HST oncogene
Homologene
FAMILY
  • heparin-binding growth factors family
  • FGF4 subfamily
  • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • fibroblast growth factor 4, basic, involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression
  • controlling limb development at the proximodistal axis
  • could promote both proliferation and differentiation of the neural progenitor cells
  • has an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain
  • having a growth-promoting role in embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at later stages of development
  • FGF4 and FGF8 are the principal FGFs required for both axis extension and limb bud outgrowth
  • FGF4 and FGF8 action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM (presomitic mesoderm) progenitor tissue
  • FGF4 and FGF8 signaling acts as the sole mediator of wavefront activity
  • role of FGF4 and MNDA in pluripotent cell responses to genotoxicity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stimulating MAP3K4 (requirement of FGF4-stimulated MAP3K4 activation of JNK for maintenance of a tissue stem cell)
  • pro-neural differentiation effect of KDM7A is mediated through direct transcriptional activation of FGF4, a signal molecule implicated in neural differentiation
  • FGF4 and FGF8 are the critical ligands for FGF signaling in the presomitic mesoderm
  • cell & other
    REGULATION
    Other ectoderm under SHH control
    ASSOCIATED DISORDERS
    corresponding disease(s) DUP11QP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS