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FLASH GENE
Symbol FEZF1 contributors: mct - updated : 07-10-2014
HGNC name FEZ family zinc finger 1
HGNC id 22788
Corresponding disease
KAL8 Kallmann syndrome 8
Location 7q31.32      Physical location : 121.941.448 - 121.944.565
Synonym name
  • zinc finger protein 312B
  • zinc finger protein 312-like
  • Synonym symbol(s) ZNF312B, FEZ, HH22
    DNA
    TYPE functioning gene
    STRUCTURE 2.55 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1955 - 425 - 2010 20431123
    4 - 2105 - 475 - 2010 20431123
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
    Respiratoryrespiratory tractlarynx  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly in embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain with homology to the canonical engrailed repressor motif
  • a KRAB domain
  • C-terminal DNA binding domain containing six C2H2 zinc-finger repeats
  • HOMOLOGY
    interspecies homolog to rattus Fezf1 (94.5 pc)
    homolog to murine Fezf1 (94.3 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcription repressor
  • involved in the axonal projection and proper termination of olfactory sensory neurons (OSN)
  • playing a role in rostro-caudal patterning of the diencephalon and in prethalamic formation
  • Regulating non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons
  • may be required for correct rostral migration of the interneuron progenitors
  • FEZF1 and FEZF2 control likely the rostro-caudal patterning of the diencephalon
  • is required for the penetration of olfactory axons through the CNS basal lamina before they innervate the olfactory bulb (OB)
  • FEZF1 and FEZF2 bind to and directly repress the promoter activity of HES5
  • FEZF1 and FEZF2 control differentiation of neural stem cells by repressing HES5 and, in turn, by derepressing neurogenin 2 in the forebrain
  • FEZF1 and FEZF2, regulate the identity of main olfactory epithelium (MOE) sensory neurons and are essential for the survival of vomeronasal organ (VNO), neurons respectively
  • FEZF1 and FEZF2 as important regulators of olfactory system development and sensory neuron identity
  • controlling neurogenesis and cell fate in the developing mammalian nervous system
  • required for establishment of the central component of the hypothalamic-pituitary-gonadal (HPG) axis
  • zinc-finger gene encoding a transcriptional repressor that is highly and selectively present during embryogenesis in the olfactory epithelium, amygdala, and hypothalamus
  • plays a role in embryonic migration of GNRH1 neurons into the brain to eventually form a hypothalamic neuronal network essential for pulsatile GNRH1 secretion and thus puberty and fertility (
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • forebrain development
  • neuron migration
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS