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FLASH GENE
Symbol FEZF1 contributors: mct - updated : 16-11-2022
HGNC name FEZ family zinc finger 1
HGNC id 22788
Corresponding disease
KAL8 Kallmann syndrome 8
Location 7q31.32      Physical location : 121.941.448 - 121.944.565
Synonym name
  • zinc finger protein 312B
  • zinc finger protein 312-like
  • Synonym symbol(s) ZNF312B, FEZ, HH22
    DNA
    TYPE functioning gene
    STRUCTURE 9.42 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2040 - 425 - 2010 20431123
    4 - 2435 - 475 - 2010 20431123
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific Homo sapiens
    Respiratoryrespiratory tractlarynx  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly in embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain with homology to the canonical engrailed repressor motif
  • a KRAB domain
  • C-terminal DNA binding domain containing six C2H2 zinc-finger repeats
  • HOMOLOGY
    interspecies homolog to rattus Fezf1 (94.5 pc)
    homolog to murine Fezf1 (94.3 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a transcription repressor
  • involved in the axonal projection and proper termination of olfactory sensory neurons (OSN)
  • playing a role in rostro-caudal patterning of the diencephalon and in prethalamic formation
  • Regulating non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons
  • may be required for correct rostral migration of the interneuron progenitors
  • FEZF1 and FEZF2 control likely the rostro-caudal patterning of the diencephalon
  • is required for the penetration of olfactory axons through the CNS basal lamina before they innervate the olfactory bulb (OB)
  • FEZF1 and FEZF2 bind to and directly repress the promoter activity of HES5
  • FEZF1 and FEZF2 control differentiation of neural stem cells by repressing HES5 and, in turn, by derepressing neurogenin 2 in the forebrain
  • FEZF1 and FEZF2, regulate the identity of main olfactory epithelium (MOE) sensory neurons and are essential for the survival of vomeronasal organ (VNO), neurons respectively
  • FEZF1 and FEZF2 as important regulators of olfactory system development and sensory neuron identity
  • controlling neurogenesis and cell fate in the developing mammalian nervous system
  • required for establishment of the central component of the hypothalamic-pituitary-gonadal (HPG) axis
  • zinc-finger gene encoding a transcriptional repressor that is highly and selectively present during embryogenesis in the olfactory epithelium, amygdala, and hypothalamus
  • plays a role in embryonic migration of GNRH1 neurons into the brain to eventually form a hypothalamic neuronal network essential for pulsatile GNRH1 secretion and thus puberty and fertility (
  • FEZF1 is necessary but not sufficient for neural differentiation from human embryonic stem cells (hESCs)
  • is an essential transcription factor during olfactory development
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • forebrain development
  • neuron migration
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • FEZF1 is transcriptionally regulated by EWSR1-FLI1 in Ewing sarcoma cells and is involved in the regulation of neural-specific genes, which could explain the neural-like phenotype observed in several Ewing sarcoma tumors and cell lines
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly increased in glioma tissues in contrast to normal brain tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FEZF1 acts as a key oncogene and predicts a poor prognosis in glioma
  • Therapy target
    SystemTypeDisorderPubmed
    reproduction  
    present a potential target for the development of novel drugs regulating hypoactive sexual desire disorder in women
    ANIMAL & CELL MODELS
  • regulator of female sexual behavior in mice