basic FUNCTION
| acting as a transcription repressor |
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involved in the axonal projection and proper termination of olfactory sensory neurons (OSN) |
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playing a role in rostro-caudal patterning of the diencephalon and in prethalamic formation |
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Regulating non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons |
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may be required for correct rostral migration of the interneuron progenitors |
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FEZF1 and FEZF2 control likely the rostro-caudal patterning of the diencephalon |
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is required for the penetration of olfactory axons through the CNS basal lamina before they innervate the olfactory bulb (OB) |
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FEZF1 and FEZF2 bind to and directly repress the promoter activity of HES5 |
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FEZF1 and FEZF2 control differentiation of neural stem cells by repressing HES5 and, in turn, by derepressing neurogenin 2 in the forebrain |
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FEZF1 and FEZF2, regulate the identity of main olfactory epithelium (MOE) sensory neurons and are essential for the survival of vomeronasal organ (VNO), neurons respectively |
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FEZF1 and FEZF2 as important regulators of olfactory system development and sensory neuron identity |
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controlling neurogenesis and cell fate in the developing mammalian nervous system |
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required for establishment of the central component of the hypothalamic-pituitary-gonadal (HPG) axis |
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zinc-finger gene encoding a transcriptional repressor that is highly and selectively present during embryogenesis in the olfactory epithelium, amygdala, and hypothalamus |
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plays a role in embryonic migration of GNRH1 neurons into the brain to eventually form a hypothalamic neuronal network essential for pulsatile GNRH1 secretion and thus puberty and fertility ( |
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FEZF1 is necessary but not sufficient for neural differentiation from human embryonic stem cells (hESCs) |
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is an essential transcription factor during olfactory development |