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FLASH GENE
Symbol FEZF1 contributors: mct - updated : 16-11-2022
HGNC name FEZ family zinc finger 1
HGNC id 22788
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain with homology to the canonical engrailed repressor motif
  • a KRAB domain
  • C-terminal DNA binding domain containing six C2H2 zinc-finger repeats
  • HOMOLOGY
    interspecies homolog to rattus Fezf1 (94.5 pc)
    homolog to murine Fezf1 (94.3 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a transcription repressor
  • involved in the axonal projection and proper termination of olfactory sensory neurons (OSN)
  • playing a role in rostro-caudal patterning of the diencephalon and in prethalamic formation
  • Regulating non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons
  • may be required for correct rostral migration of the interneuron progenitors
  • FEZF1 and FEZF2 control likely the rostro-caudal patterning of the diencephalon
  • is required for the penetration of olfactory axons through the CNS basal lamina before they innervate the olfactory bulb (OB)
  • FEZF1 and FEZF2 bind to and directly repress the promoter activity of HES5
  • FEZF1 and FEZF2 control differentiation of neural stem cells by repressing HES5 and, in turn, by derepressing neurogenin 2 in the forebrain
  • FEZF1 and FEZF2, regulate the identity of main olfactory epithelium (MOE) sensory neurons and are essential for the survival of vomeronasal organ (VNO), neurons respectively
  • FEZF1 and FEZF2 as important regulators of olfactory system development and sensory neuron identity
  • controlling neurogenesis and cell fate in the developing mammalian nervous system
  • required for establishment of the central component of the hypothalamic-pituitary-gonadal (HPG) axis
  • zinc-finger gene encoding a transcriptional repressor that is highly and selectively present during embryogenesis in the olfactory epithelium, amygdala, and hypothalamus
  • plays a role in embryonic migration of GNRH1 neurons into the brain to eventually form a hypothalamic neuronal network essential for pulsatile GNRH1 secretion and thus puberty and fertility (
  • FEZF1 is necessary but not sufficient for neural differentiation from human embryonic stem cells (hESCs)
  • is an essential transcription factor during olfactory development
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • forebrain development
  • neuron migration
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • FEZF1 is transcriptionally regulated by EWSR1-FLI1 in Ewing sarcoma cells and is involved in the regulation of neural-specific genes, which could explain the neural-like phenotype observed in several Ewing sarcoma tumors and cell lines
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly increased in glioma tissues in contrast to normal brain tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FEZF1 acts as a key oncogene and predicts a poor prognosis in glioma
  • Therapy target
    SystemTypeDisorderPubmed
    reproduction  
    present a potential target for the development of novel drugs regulating hypoactive sexual desire disorder in women
    ANIMAL & CELL MODELS
  • regulator of female sexual behavior in mice