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FLASH GENE
Symbol FES contributors: mct - updated : 07-12-2001
HGNC name feline sarcoma oncogene
HGNC id 3657
Location 15q26.1      Physical location : 91.427.664 - 91.439.004
Synonym name
  • viral (v-fps) oncogene homolog
  • c-fes/fps protein
  • feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
  • oncogene FES, feline sarcoma virus", "c-fes/fps protein
  • proto-oncogene c-fes variant
  • proto-oncogene tyrosine-protein kinase Fes/Fps
    • Synonym symbol(s) FPS, C-Fes
    EC.number 2.7.1.112/ 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 11.34 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter methylation is an important mechanism responsible for downregulation of FES gene expression in colorectal cancer cells (Shaffer 2009)
    MAPPING cloned Y linked Y status confirmed
    Map cen - D15S95 - D15S111 - BLM - D15S127 - FURIN - FES- D15S158 - D15S100 - D15S107 - IGF1R - D15S87 - qter
    Authors Butler (94), Ellis (95)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2783 93.3 822 - 2010 20117079
    isoform 1
    17 - 2513 86.5 764 - 2010 20117079
  • variant 2 lacks an in-frame exon in the 5' coding region
  • isoform 2
    • 17 - 2477 85.33 752 - 2010 20117079
  • variant 3 lacks an in-frame exon in the 3' coding region
  • isoform 3
    • 17 - 2422 78.5 694 - 2010 20117079
  • variant 4 lacks multiple in-frame exons in the coding region
  • isoform 4
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique N-terminal region
  • two coiled-coil (CC) domains (CC1 and CC2) critical regulators of Fes activity and that may function to recruit Fes activators and/or substratesa FCH domain
  • a protein kinase domain
  • a SH2 domain
    • HOMOLOGY
    interspecies homolog to Fujinami avian sarcoma viral (v-fps) oncogene
    homolog to murine Fes (90.6pc)
    homolog to rattus Fes (91.5pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • Fes/fps subfamily
    • CATEGORY enzyme , tumor suppressor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • having tyrosine-specific protein kinase activity, required for maintenance of cellular transformation
  • implicated in the differentiation of a number of cell types including neuronal, endothelial and myeloid cells
  • tumor suppressor gene in colorectal cancer (Shaffer 2009)
  • required for KITLG-induced chemotaxis, mediator of KIT signalling implicated in cell migration (Voisset 2010)
  • implicated in regulating cross-talk between KIT and beta1 integrins to promote cytoskeletal reorganization and motility of mast cells
  • is an SH2-containing tyrosine kinase protein, and this domain enhances catalytic activity and substrate recognition
  • PLD2 and FES might be physically associated, which could be beneficial for a quick transduction of the activating signal within the cell
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • new signaling pathway (JAK-FES-PLD2) that is enhanced in highly proliferative breast cancer cells
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRIM28 (FES-TRIM28 interaction, with a dual role for TRIM28 as both a FES activator and downstream effector)
  • interacting with KIT (Voisset 2010)
  • JAK3, FES and PLD2 interactions in transformed cells maintain PLD2 at an enhanced level that leads to abnormal cell growth
    • cell & other
    REGULATION
    Other phosphorylated following KIT activation by its ligand KITLG (Voisset 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colon tumor and colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    its inhibition might provide therapeutic benefits in breast cancer, in part by attenuating tumor-associated angiogenesis and the metastasis-promoting functions of tumor-associated macrophages
    ANIMAL & CELL MODELS