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FLASH GENE
Symbol FES contributors: mct - updated : 07-12-2001
HGNC name feline sarcoma oncogene
HGNC id 3657
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2783 93.3 822 - 2010 20117079
isoform 1
17 - 2513 86.5 764 - 2010 20117079
  • variant 2 lacks an in-frame exon in the 5' coding region
  • isoform 2
    • 17 - 2477 85.33 752 - 2010 20117079
  • variant 3 lacks an in-frame exon in the 3' coding region
  • isoform 3
    • 17 - 2422 78.5 694 - 2010 20117079
  • variant 4 lacks multiple in-frame exons in the coding region
  • isoform 4
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique N-terminal region
  • two coiled-coil (CC) domains (CC1 and CC2) critical regulators of Fes activity and that may function to recruit Fes activators and/or substratesa FCH domain
  • a protein kinase domain
  • a SH2 domain
    • HOMOLOGY
    interspecies homolog to Fujinami avian sarcoma viral (v-fps) oncogene
    homolog to murine Fes (90.6pc)
    homolog to rattus Fes (91.5pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • Fes/fps subfamily
    • CATEGORY enzyme , tumor suppressor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • having tyrosine-specific protein kinase activity, required for maintenance of cellular transformation
  • implicated in the differentiation of a number of cell types including neuronal, endothelial and myeloid cells
  • tumor suppressor gene in colorectal cancer (Shaffer 2009)
  • required for KITLG-induced chemotaxis, mediator of KIT signalling implicated in cell migration (Voisset 2010)
  • implicated in regulating cross-talk between KIT and beta1 integrins to promote cytoskeletal reorganization and motility of mast cells
  • is an SH2-containing tyrosine kinase protein, and this domain enhances catalytic activity and substrate recognition
  • PLD2 and FES might be physically associated, which could be beneficial for a quick transduction of the activating signal within the cell
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • new signaling pathway (JAK-FES-PLD2) that is enhanced in highly proliferative breast cancer cells
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRIM28 (FES-TRIM28 interaction, with a dual role for TRIM28 as both a FES activator and downstream effector)
  • interacting with KIT (Voisset 2010)
  • JAK3, FES and PLD2 interactions in transformed cells maintain PLD2 at an enhanced level that leads to abnormal cell growth
    • cell & other
    REGULATION
    Other phosphorylated following KIT activation by its ligand KITLG (Voisset 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colon tumor and colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    its inhibition might provide therapeutic benefits in breast cancer, in part by attenuating tumor-associated angiogenesis and the metastasis-promoting functions of tumor-associated macrophages
    ANIMAL & CELL MODELS