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FLASH GENE
Symbol FBXO31 contributors: mct - updated : 10-09-2009
HGNC name F-box protein 31
HGNC id 16510
Location 16q24.2      Physical location : 87.362.943 - 87.425.708
Synonym name
  • F-box only protein 31
  • SCF ubiquitin ligase specificity factor
  • putative breast cancer tumor-suppressor
  • Synonym symbol(s) FBX14, Fbx31, FBXO14, MGC9527, FLJ22477, MGC15419, pp2386
    DNA
    TYPE functioning gene
    STRUCTURE 62.76 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3636 - - - Santra (2009)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunetonsils   highly
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a F-box domain, and is associated with the proteins Skp1, Roc-1, and Cullin-1
    HOMOLOGY
    Homologene
    FAMILY cyclin-like F-box family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • putative breast cancer tumor-suppressor
  • can induce cellular senescence in the breast cancer cell line
  • regulator of the G1/S transition that is specifically required for DNA damage-induced growth arrest (Santra 2009)
  • functions as a tumor suppressor by generating SCF(FBXO31) complexes that target particular substrates, critical for the normal execution of the cell cycle, for ubiquitination and subsequent degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by variety of DNA damaging agents (induction of FBXO31 is a general response to genotoxic stress) (Santra 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast tumor cell lines and primary tumors
    constitutional     --other  
    ectopic expression of FBXO31 acts through a proteasome-directed pathway to mediate the degradation of cyclin D1, an important regulator of progression from G1 to S phase, resulting in arrest in G1 (Santra 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate senescence gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS