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FLASH GENE
Symbol FBXO31 contributors: mct - updated : 10-09-2009
HGNC name F-box protein 31
HGNC id 16510
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a F-box domain, and is associated with the proteins Skp1, Roc-1, and Cullin-1
HOMOLOGY
Homologene
FAMILY cyclin-like F-box family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,nucleus
basic FUNCTION
  • putative breast cancer tumor-suppressor
  • can induce cellular senescence in the breast cancer cell line
  • regulator of the G1/S transition that is specifically required for DNA damage-induced growth arrest (Santra 2009)
  • functions as a tumor suppressor by generating SCF(FBXO31) complexes that target particular substrates, critical for the normal execution of the cell cycle, for ubiquitination and subsequent degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by variety of DNA damaging agents (induction of FBXO31 is a general response to genotoxic stress) (Santra 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast tumor cell lines and primary tumors
    constitutional     --other  
    ectopic expression of FBXO31 acts through a proteasome-directed pathway to mediate the degradation of cyclin D1, an important regulator of progression from G1 to S phase, resulting in arrest in G1 (Santra 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate senescence gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS