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FLASH GENE
Symbol FAM175B contributors: mct - updated : 26-03-2014
HGNC name family with sequence similarity 175, member B
HGNC id 28975
Location 10q26.2      Physical location : 126.490.353 - 126.525.238
Synonym name
  • hypothetical protein KIAA0157
  • Abraxas brother 1
    • Synonym symbol(s) KIAA0157, Em:AC068896.4, ABRO1, FLJ22338
    DNA
    TYPE functioning gene
    STRUCTURE 34.89 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3008 47 415 - 2009 19214193
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • FAM175 family
    • CATEGORY storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • mainly localized in the cytoplasm
  • mainly localizes in cytosol and activates BRCC3 in the cytoplasm
  • is predominantly cytoplasmic, but during cellular stress it enters the nucleus and co-localizes with ATF4
    • basic FUNCTION
  • scaffold protein that recruits polypeptides to assemble the BRISC (BRCC36-containing isopeptidase complex) deubiquitinating (DUB) enzyme
  • scaffold protein that recruits various polypeptides to assemble the BRISC (BRCC3 isopeptide) deubiquitinating enzyme (DUB) complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of BRCC3 isopeptidase complex (BRISC) with BRCC3, BRE, MERIT40, and FAM175B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BRCC3 associates with another protein FAM175B, which shares significant sequence homology with FAM175A
  • specific interactor of THAP5, a zinc finger transcription factor that is involved in G2/M control and apoptosis
  • has a cytoprotective role that involves the BRISC DUB complex acting on specific Lys63-linked polyubiquitinated substrates
  • FAM175B interaction with ATF4 is necessary and essential for the cytoprotective function of FAM175B following oxidative stress
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in myocardial injury and coronary artery disease and this up-regulation is part of a novel cardioprotective mechanism
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS