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FLASH GENE
Symbol FAM175B contributors: mct - updated : 26-03-2014
HGNC name family with sequence similarity 175, member B
HGNC id 28975
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • FAM175 family
    • CATEGORY storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • mainly localized in the cytoplasm
  • mainly localizes in cytosol and activates BRCC3 in the cytoplasm
  • is predominantly cytoplasmic, but during cellular stress it enters the nucleus and co-localizes with ATF4
    • basic FUNCTION
  • scaffold protein that recruits polypeptides to assemble the BRISC (BRCC36-containing isopeptidase complex) deubiquitinating (DUB) enzyme
  • scaffold protein that recruits various polypeptides to assemble the BRISC (BRCC3 isopeptide) deubiquitinating enzyme (DUB) complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of BRCC3 isopeptidase complex (BRISC) with BRCC3, BRE, MERIT40, and FAM175B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BRCC3 associates with another protein FAM175B, which shares significant sequence homology with FAM175A
  • specific interactor of THAP5, a zinc finger transcription factor that is involved in G2/M control and apoptosis
  • has a cytoprotective role that involves the BRISC DUB complex acting on specific Lys63-linked polyubiquitinated substrates
  • FAM175B interaction with ATF4 is necessary and essential for the cytoprotective function of FAM175B following oxidative stress
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in myocardial injury and coronary artery disease and this up-regulation is part of a novel cardioprotective mechanism
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS