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FLASH GENE
Symbol FABP3 last update : 14-12-2005
HGNC name fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
HGNC id 3557
Location 1p33-p32
Synonym name mammary derived growth inhibitor
Synonym symbol(s) MDGI, HFABP, FABP11, H-FABP, O-FABP
DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MATN1 1p35.1-p34.3 matrilin 1, cartilage matrix protein LAPTM5 1p34 matrilin 1, cartilage matrix protein LOC388616 1 LOC388616 SDC3 1pter-p22.3 syndecan 3 (N-syndecan) PUM1 1p35.2 pumilio homolog 1 (Drosophila) SEPW1P 1p34-p35 selenoprotein W, 1 pseudogene FLJ12650 1p35.1 hypothetical protein FLJ12650 HPRP8BP 1p35.1 U5 snRNP-specific 40 kDa protein (hPrp8-binding) PS1D 1p35.1 putative S1 RNA binding domain protein FABP3 1p33-p32 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) TDE2L 1p35.1 tumor differentially expressed 2-like LOC127572 1p35.1 similar to elongation factor 1 alpha LOC149086 1p35.1 hypothetical protein LOC149086 LCN7 1p34.3 lipocalin 7 HCRTR1 1p33 hypocretin (orexin) receptor 1 PEF 1p34 hypocretin (orexin) receptor 1 COL16A1 1p34.3 collagen, type XVI, alpha 1 BAI2 1p35 brain-specific angiogenesis inhibitor 2 FLJ25348 1p35.1 hypothetical protein FLJ25348 PTP4A2 1p36 protein tyrosine phosphatase type IVA, member 2 KHDRBS1 1p32 KH domain containing, RNA binding, signal transduction associated 1 FLJ10315 1p34.3 hypothetical protein FLJ10315 KPNA6 1p35-p34.1 karyopherin alpha 6 (importin alpha 7) DKFZp451J0118 1p34.3 taxilin MGC1203 1p36.11-p34.2 hypothetical protein MGC1203 FLJ10547 1p36.11-p34.2 hypothetical protein FLJ10547 RP4-622L5 1p36.11-p34.2 hypothetical protein RP4-622L5 EIF3S2 1p34.1 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa LOC339483 1p34.3 hypothetical protein LOC339483
RNA
TRANSCRIPTS type messenger
EXPRESSION / SUBCELLULAR LOCALIZATION
EXPRESSION (based on citations)
constitutive of
   expressed in
organ(s)
SystemOrgan 1organ 2organ 3organ 4level
Cardiovascularheart    
tissue
SystemTissueS_TissueSs_Tissuelevel
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
repeated structure + topology beta barrel and remarkable structural signature
HOMOLOGY
interspecies
 
 homolog to murine Fabp3
intraspecies
 
Homologene
FAMILY lipocalin/calycins family (FABP/CRBP family of transporters)
CATEGORY tumor suppressor , transport carrier
basic FUNCTION
  • fatty acid binding protein, tumor suppressor for breast cancer
  • participating in the uptake, intracellular metabolism and/or transport of long-chain fatty acids
    • implicated in a
    process
    cellular process
    physiological
    pathway
    metabolism
    signaling
    a component
    structural
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Therapy target
    animal or cellular model