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FLASH GENE
Symbol FABP3 contributors: mct - updated : 17-08-2011
HGNC name fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
HGNC id 3557
Location 1p35.2      Physical location : 31.838.099 - 31.845.923
Synonym name mammary derived growth inhibitor
Synonym symbol(s) MDGI, HFABP, FABP11, H-FABP, O-FABP
DNA
TYPE functioning gene
STRUCTURE 7.82 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MATN1 1p35.1-p34.3 matrilin 1, cartilage matrix protein LAPTM5 1p34 matrilin 1, cartilage matrix protein LOC388616 1 LOC388616 SDC3 1pter-p22.3 syndecan 3 (N-syndecan) PUM1 1p35.2 pumilio homolog 1 (Drosophila) SEPW1P 1p34-p35 selenoprotein W, 1 pseudogene FLJ12650 1p35.1 hypothetical protein FLJ12650 HPRP8BP 1p35.1 U5 snRNP-specific 40 kDa protein (hPrp8-binding) PS1D 1p35.1 putative S1 RNA binding domain protein FABP3 1p33-p32 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) TDE2L 1p35.1 tumor differentially expressed 2-like LOC127572 1p35.1 similar to elongation factor 1 alpha LOC149086 1p35.1 hypothetical protein LOC149086 LCN7 1p34.3 lipocalin 7 HCRTR1 1p33 hypocretin (orexin) receptor 1 PEF 1p34 hypocretin (orexin) receptor 1 COL16A1 1p34.3 collagen, type XVI, alpha 1 BAI2 1p35 brain-specific angiogenesis inhibitor 2 FLJ25348 1p35.1 hypothetical protein FLJ25348 PTP4A2 1p36 protein tyrosine phosphatase type IVA, member 2 KHDRBS1 1p32 KH domain containing, RNA binding, signal transduction associated 1 FLJ10315 1p34.3 hypothetical protein FLJ10315 KPNA6 1p35-p34.1 karyopherin alpha 6 (importin alpha 7) DKFZp451J0118 1p34.3 taxilin MGC1203 1p36.11-p34.2 hypothetical protein MGC1203 FLJ10547 1p36.11-p34.2 hypothetical protein FLJ10547 RP4-622L5 1p36.11-p34.2 hypothetical protein RP4-622L5 EIF3S2 1p34.1 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa LOC339483 1p34.3 hypothetical protein LOC339483
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1097 - 133 - 2010 20802519
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Hearing/Equilibriumearinnercochlea   Homo sapiens
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
repeated structure + topology beta barrel and remarkable structural signature
HOMOLOGY
interspecies homolog to murine Fabp3
Homologene
FAMILY lipocalin/calycins family (FABP/CRBP family of transporters)
CATEGORY tumor suppressor , transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text
  • localized in inner and outer pillar cells and outer phalangeal cells
  • basic FUNCTION
  • fatty acid binding protein, tumor suppressor for breast cancer
  • participating in the uptake, intracellular metabolism and/or transport of long-chain fatty acids
  • support potentially fat accumulation in the hypoxic placenta
  • play important roles in the regulation of the hearing function
  • heart-type fatty acid-binding protein, essential for cold tolerance and efficient fatty acid oxidation, in brown adipose tissue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel interacting partner for integrin alpha-subunits, and its expression modulates integrin activity and suppresses cell invasion in breast cancer patients
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    aberrant expression may alter membrane fluidity and signal transduction, and consequently could be involved in cellular dysfunction in neurodegenerative disorders
    Susceptibility to essential hypertension (EH)
    Variant & Polymorphism SNP
  • G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects
  • Candidate gene
    Marker
  • useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid
  • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    potential target for modulation of energy dissipation
    ANIMAL & CELL MODELS
  • Fabp3(-/-) mice exhibit extreme cold sensitivity despite induction of uncoupling and oxidative genes and hydrolysis of brown adipose tissue lipid store