protein
| thrombin |
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coupled to calcium, ERK, and AKT signaling (modulating growth in native lens tissue and cultured cells) |
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F2R stimulation upregulates the expression of the suppressor of cytokine signaling-3 (SOCS3) |
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interacting with EDG3, SPHK1 (signaling controls dissemination of inflammation from the lymphatics) |
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BICD1 is a direct interactor with the C-terminal cytoplasmic domain of F2R |
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link between F2R signal termination and internalization through the non-G protein effector, BICD1 |
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F2R and F2RL3 are functionally expressed in large myelinated fibre neurons, and are also expressed in small nociceptors of the peptidergic subclass, where they are able to potentiate TRPV1 activity |
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occupancy of PROCR by its natural ligand modulates the F2R-dependent signaling specificity of coagulation proteases |
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MMP1 is an important activator of F2R in sepsis |
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interaction between F2R and F2RL3, F2RL3 also interacts with the P2Y12 receptor on platelets to alter signaling |
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interacting with GZMK (extracellular GZMK is capable of activating F2R and inducing fibroblast cytokine secretion and proliferation) |
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interacting with EPN1 (adaptor protein complex-2 and EPN1 are both critical mediators of agonist-stimulated F2R internalization) |
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thrombin activates platelets by binding and cleaving protease-activated receptors F2R and F2RL3 |
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F3 mediates signalling through coagulation proteases that activate the G-protein-coupled receptors F2R and F2RL1 |
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MMP1 is a collagenase and activator of the G protein-coupled protease activated receptor-1 (F2R) |
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PDCD6IP binds to F2R, recruits ESCRT-III, and mediates receptor sorting to intraluminal vesicles (ILVs) of multivesicular bodies (MVBs)/lysosomes |
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AP3B1 facilitates F2R interaction with PDCD6IP, suggesting that AP3B1 functions before F2R engagement of PDCD6IP and multivesicular bodies (MVBs)/lysosomes sorting |
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F3 participates in protease-activated receptor F2R and F2RL1 activation |
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correlation between F2R and FGFR1 suggests an association of the two receptors with a more aggressive breast cancer phenotype and, consequently, a potential role during tumor progression |
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thrombin binds to and cleaves the N terminus of F2R, generating a new N terminus that functions as a tethered ligand that cannot diffuse away |
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TFAP2A regulates activated F2R signaling by altering receptor surface expression and through recruitment of regulator of G protein signaling (RGS) proteins |
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RAB11B is a critical regulator of F2R trafficking |
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RAB11A and RAB11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms |
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F2R agonist is MMP1 |
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thrombin upregulates LCN2 through F2R activation and causes brain damage in brain injury |
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KLK6-F2R-mediated inflammation in the skin alone is sufficient to drive inflammatory joint disease |