| 1 | F2R, KLK6
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| KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
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| Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruszka D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL.
|
| J Clin Invest Clin Invest. 2020 Mar 10. pii: 133159. doi: 10.1172/JCI133159. [Epub ahead of print]
2020
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| 2 | F2R, LCN2
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| Role of Lipocalin-2 in Thrombin-Induced Brain Injury.
|
| Mao S, Xi G, Keep RF, Hua Y.
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| Stroke 47(4):1078-84. doi: 10.1161/STROKEAHA.115.012153.
2016
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| 3 | F2R, RAB11A, RAB11B
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| Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
|
| Grimsey NJ, Coronel LJ, Cordova IC, Trejo J.
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| J Biol Chem 291(5):2223-36. doi: 10.1074/jbc.M115.702993.
2016
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| 4 | F2R, MMP1
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| The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells.
|
| Valente MM, Allen M, Bortolotto V, Lim ST, Conant K, Grilli M.
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| Neural Plast 2015:646595. doi: 10.1155/2015/646595.
2015
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| 5 | F2R
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| Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection.
|
| José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown JS, Chambers RC.
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| J Immunol 194(12):6024-34. doi: 10.4049/jimmunol.1500124.
2015
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| 6 | F2R
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| Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis.
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| Isaev D, Lushnikova I, Lunko O, Zapukhliak O, Maximyuk O, Romanov A, Skibo GG, Tian C, Holmes GL, Isaeva E.
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| Neurobiol Dis 78:68-76. doi: 10.1016/j.nbd.2015.03.026.
2015
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| 7 | F2R
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| PAR1-stimulated platelet releasate promotes angiogenic activities of endothelial progenitor cells more potently than PAR4-stimulated platelet releasate.
|
| Huang Z, Miao X, Luan Y, Zhu L, Kong F, Lu Q, Pernow J, Nilsson G, Li N.
|
| J Thromb Haemost 13(3):465-76. doi: 10.1111/jth.12815.
2015
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| 8 | F2R
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| Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets.
|
| Arachiche A, de la Fuente M, Nieman MT.
|
| PLoS One 9(5):e97724. doi: 10.1371/journal.pone.0097724.
2014
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| 9 | F2R
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| Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.
|
| Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, Bäumer S, Berdel WE, Müller-Tidow C, Tickenbrock L.
|
| PLoS One 9(4):e94993. doi: 10.1371/journal.pone.0094993.
2014
|
| 10 | F2R
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| Expression pattern of protease activated receptors in lymphoid cells.
|
| López ML, Soriano-Sarabia N, Bruges G, Marquez ME, Preissner KT, Schmitz ML, Hackstein H.
|
| Cell Immunol 288(1-2):47-52. doi: 10.1016/j.cellimm.2014.02.004.
2014
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| 11 | F2R, TFAP2A
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| Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.
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| Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J.
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| J Biol Chem 289(3):1580-91. doi: 10.1074/jbc.M113.528273.
2014
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| 12 | F2R, F2RL1, F3
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| Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.
|
| Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW.
|
| Am J Respir Cell Mol Biol 48(1):94-104. doi: 10.1165/rcmb.2012-0189OC. Epub 2012 Oct 11.
2013
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| 13 | F2R, F2RL1
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| Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling.
|
| Lin H, Trejo J.
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| J Biol Chem 288(16):11203-15. doi: 10.1074/jbc.M112.439950. Epub 2013 Mar 8.
2013
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| 14 | F2R
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| A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure.
|
| Aronovich A, Nur Y, Shezen E, Rosen C, Zlotnikov Klionsky Y, Milman I, Yarimi L, Hagin D, Rechavi G, Martinowitz U, Nagasawa T, Frenette PS, Tchorsh-Yutsis D, Reisner Y.
|
| Blood 122(15):2562-71. doi: 10.1182/blood-2012-08-447458.
2013
|
| 15 | F2R
|
| Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting.
|
| Canto I, Trejo J.
|
| J Biol Chem 288(22):15900-12. doi: 10.1074/jbc.M113.469866.
2013
|
| 16 | F2R, F8
|
| A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure.
|
| Aronovich A, Nur Y, Shezen E, Rosen C, Zlotnikov Klionsky Y, Milman I, Yarimi L, Hagin D, Rechavi G, Martinowitz U, Nagasawa T, Frenette PS, Tchorsh-Yutsis D, Reisner Y.
|
| Blood 122(15):2562-71. doi: 10.1182/blood-2012-08-447458.
2013
|
| 17 | F2R, F2RL1, KLK6
|
| Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.
|
| Yoon H, Radulovic M, Wu J, Blaber SI, Blaber M, Fehlings MG, Scarisbrick IA.
|
| J Neurochem 127(2):283-98. doi: 10.1111/jnc.12293. Epub 2013 May 27.
2013
|
| 18 | F2R, FGFR1
|
| Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas: Prognostic significance.
|
| Tiburcio M, Costa SM, DE Fatima Duarte M, Schmitt FC, Longatto Filho A.
|
| Oncol Lett 4(4):647-657. Epub 2012 Jul 17.
2012
|
| 19 | F2R, MMP1
|
| Matrix metalloprotease-1a promotes tumorigenesis and metastasis.
|
| Foley CJ, Luo C, O'Callaghan K, Hinds PW, Covic L, Kuliopulos A.
|
| J Biol Chem 287(29):24330-8. doi: 10.1074/jbc.M112.356303. Epub 2012 May 9.
2012
|
| 20 | F2R, F2RL1, F3
|
| Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling.
|
| Reinhardt C, Bergentall M, Greiner TU, Schaffner F, Ostergren-Lundén G, Petersen LC, Ruf W, Bäckhed F.
|
| Nature 483(7391):627-31. doi: 10.1038/nature10893.
2012
|
| 21 | F2R, F2RL3
|
| Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4.
|
| de la Fuente M, Noble DN, Verma S, Nieman MT.
|
| J Biol Chem 287(13):10414-23. doi: 10.1074/jbc.M112.341438. Epub 2012 Feb 8.
2012
|
| 22 | AP3B1, F2R, PDCD6IP
|
| AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway.
|
| Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J.
|
| Mol Biol Cell 23(18):3612-23. doi: 10.1091/mbc.E12-03-0251.
2012
|
| 23 | EPN1, F2R
|
| Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.
|
| Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J.
|
| J Biol Chem 286(47):40760-70. Epub 2011 Sep 30.
2011
|
| 24 | F2R, F2RL1
|
| Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia.
|
| Sevigny LM, Austin KM, Zhang P, Kasuda S, Koukos G, Sharifi S, Covic L, Kuliopulos A.
|
| Arterioscler Thromb Vasc Biol 31(12):e100-6. Epub 2011 Sep 22.
2011
|
| 25 | F2R, GZMK
|
| Granzyme K activates protease-activated receptor-1.
|
| Cooper DM, Pechkovsky DV, Hackett TL, Knight DA, Granville DJ.
|
| PLoS One 6(6):e21484. Epub 2011 Jun 30.
2011
|
| 26 | F2R, MMP1
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| A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.
|
| Tressel SL, Kaneider NC, Kasuda S, Foley C, Koukos G, Austin K, Agarwal A, Covic L, Opal SM, Kuliopulos A.
|
| EMBO Mol Med 3(7):370-84. doi: 10.1002/emmm.201100145. Epub 2011 May 18. 2011
|
| 27 | F2R
|
| Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus.
|
| Han KS, Mannaioni G, Hamill CE, Lee J, Junge CE, Lee CJ, Traynelis SF.
|
| Mol Brain 4:32.
2011
|
| 28 | F2R
|
| Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias.
|
| Veiga Cde S, Carneiro-Lobo TC, Coelho CJ, Carvalho SM, Maia RC, Vasconcelos FC, Abdelhay E, Mencalha AL, Ferreira AF, Castro FA, Monteiro RQ.
|
| Blood Cells Mol Dis 46(3):230-4. Epub 2011 Jan 7.
2011
|
| 29 | F2R, MMP1
|
| A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.
|
| Tressel SL, Kaneider NC, Kasuda S, Foley C, Koukos G, Austin K, Agarwal A, Covic L, Opal SM, Kuliopulos A.
|
| EMBO Mol Med 3(7):370-84. doi: 10.1002/emmm.201100145. Epub 2011 May 18.
2011
|
| 30 | F2R, PROCR
|
| The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases.
|
| Rezaie AR.
|
| IUBMB Life 63(6):390-6. doi: 10.1002/iub.447. Epub 2011 Mar 24. Review. 2011
|
| 31 | F2R
|
| The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.
|
| Fujimoto D, Hirono Y, Goi T, Katayama K, Matsukawa S, Yamaguchi A.
|
| BMC Cancer 10:443.
2010
|
| 32 | F2R
|
| Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.
|
| Gandhi PS, Chen Z, Di Cera E.
|
| J Biol Chem 285(20):15393-8. Epub 2010 Mar 17.
2010
|
| 33 | BICD1, F2R
|
| A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.
|
| Swift S, Xu J, Trivedi V, Austin KM, Tressel SL, Zhang L, Covic L, Kuliopulos A.
|
| J Biol Chem 285(15):11402-10. Epub 2010 Feb 17.
2010
|
| 34 | F2R
|
| Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype.
|
| Silini A, Ghilardi C, Ardinghi C, Bernasconi S, Oliva P, Carraro F, Naldini A, Bani MR, Giavazzi R.
|
| Clin Exp Metastasis 27(1):43-53. Epub 2009 Dec 20.
2010
|
| 35 | F2R, F2RL3
|
| Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
|
| Vellani V, Kinsey AM, Prandini M, Hechtfischer SC, Reeh P, Magherini PC, Giacomoni C, McNaughton PA.
|
| Mol Pain 6:61. doi: 10.1186/1744-8069-6-61.
2010
|
| 36 | F2R
|
| Protease-activated receptor-1 regulates cytokine production and induces the suppressor of cytokine signaling-3 in microglia.
|
| Fabrizi C, Pompili E, Panetta B, Nori SL, Fumagalli L.
|
| Int J Mol Med 24(3):367-71.
2009
|
| 37 | F2R, PROC
|
| Caveolae are required for protease-selective signaling by protease-activated receptor-1.
|
| Russo A, Soh UJ, Paing MM, Arora P, Trejo J.
|
| Proc Natl Acad Sci U S A 106(15):6393-7. Epub 2009 Mar 30.
2009
|
| 38 | F2R, F2RL1
|
| Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase.
|
| Suzuki H, Motley ED, Eguchi K, Hinoki A, Shirai H, Watts V, Stemmle LN, Fields TA, Eguchi S.
|
| Hypertension 53(2):182-8. Epub 2008 Dec 8.
2009
|
| 39 | F2R, S1PR3
|
| Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.
|
| Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W.
|
| Nature 452(7187):654-8. Epub 2008 Feb 27. 2008
|
| 40 | F2R, F2RL2
|
| Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization.
|
| McLaughlin JN, Patterson MM, Malik AB.
|
| Proc Natl Acad Sci U S A 104(13):5662-7. Epub 2007 Mar 21.
2007
|
| 41 | F2R
|
| PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.
|
| Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, Kuliopulos A.
|
| Cell 120(3):303-13. 2005
|
| 42 | F2R
|
| Identification of a novel functional androgen response element within hPar1 promoter: implications to prostate cancer progression.
|
| Salah Z, Maoz M, Cohen I, Pizov G, Pode D, Runge MS, Bar-Shavit R.
|
| FASEB J 19(1):62-72. 2005
|
| 43 | F2R
|
| Characterization and functional activity of thrombin receptors in the human lens.
|
| James C, Collison DJ, Duncan G.
|
| Invest Ophthalmol Vis Sci 46(3):925-32. 2005
|
| 44 | F2R
|
| A role for thrombin receptor signaling in endothelial cells during embryonic development.
|
| Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR.
|
| Science 293(5535):1666-70. 2001
|
| 45 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
|
| Sequence diversity in 36 candidate genes for cardiovascular disorders.
|
| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
|
| Am J Hum Genet 65(1):183-91. 1999
|
| 46 | F2R, F2RL3
|
| Cloning and characterization of human protease-activated receptor 4.
|
| Xu W, et al.
|
| Proc Natl Acad Sci U S A 95 : 6642-6646. 1998
|
| 47 | F2R, F2RL1, F2RL2
|
| Protease-activated receptor genes are clustered on 5q13.
|
| Guyonnet Duperat V, et al.
|
| Blood 92 : 25-31. 1998
|
| 48 | F2R, F2RL1, F2RL2
|
| Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.
|
| Kahn ML, et al.
|
| J Biol Chem 273 : 23290-23296. 1998
|
| 49 | F2R, F2RL1
|
| The human thrombin receptor and proteinase activated receptor-2 genes are tightly linked on chromosome 5q13.
|
| Schmidt VA, Nierman WC, Feldblyum TV, Maglott DR, Bahou WF.
|
| Br J Haematol 97(3):523-9. 1997
|
| 50 | F2R
|
| The human thrombin receptor gene and the 5q-syndrome.
|
| Bahou WF, et al.
|
| Leuk Lymphoma 27 : 1-10. 1997
|
| 51 | F2R
|
| The thrombin receptor gene is centromeric to the common proximal breakpoint in patients with the 5q-syndrome : identification of a previously unrecognized chromosome 5 inversion.
|
| Demetrick DJ, et al.
|
| Br J Haematol 92 : 339-343. 1996
|
| 52 | F2R
|
| Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene.
|
| Schmidt VA, et al.
|
| J Biol Chem 271 : 9307-9312. 1996
|
| 53 | F2R
|
| Cloning and identification of regulatory sequences of the human thrombin receptor gene.
|
| Li F, et al.
|
| J Biol Chem 271 : 26320-26328. 1996
|
| 54 | F2R
|
| Chromosomal assignment of the human thrombin receptor gene : localization to region q13 of chromosome 5.
|
| Bahou WF, et al.
|
| Blood 82 : 1532-1537. 1993
|