basic FUNCTION
| transcriptional repressor in tumor cells activated as they become metastatic |
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playing a role in vascular invasion and breast cancer metastasis |
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implicated in the process of cellular differentiation and cancer progression for both breast and prostate cancer |
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exerting its epigenetic function through regulation of histone methylation |
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a critical role in early B cell development and rearrangement of the immunoglobulin heavy chain gene and a key regulator of histone H3 methylation in early B cell progenitors ( |
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regulation of actin polymerization ( |
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may be involved in the regulation of gene transcription and chromatin structure |
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acting as a methyltransferase |
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may play a role in the hematopoietic and central nervous systems |
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required for DNA methylation of EZH2-target promoters |
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regulates muscle gene expression and skeletal muscle differentiation ( |
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serves as a recruitment platform for DNA methyltransferases ( |
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EZH1, EZH2 maintain repressive chromatin through different mechanisms |
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might have a central role in Ewing tumor pathology by shaping the oncogenicity and stem cell phenotype of this tumor |
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important in ER-negative breast cancer growth |
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histone methyltransferase that constitutes the catalytic unit of the polycomb repressive complex 2 (PRC2) |
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catalytic subunit of the polycomb repressive complex 2 (PRC2), a highly conserved histone H3 lysine 27 (H3K27) methyltransferase that influences stem cell renewal by epigenetic repression of genes involved in cell fate decisions |
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acting as a tumor suppressor for myeloid malignancies |
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acts as a codominant tumor suppressor for myelopoiesis ) |
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essential for controlling the rate at which development progresses within cortical progenitor cell lineages |
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catalytic subunit of the PRC2 Polycomb complex and mediates transcriptional repression through its histone methyltransferase activity |
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involved in regulating a specific epigenetic program in normal germinal centers, including silencing of antiproliferative genes, which may contribute to the malignant transformation of germinal center B cells into diffuse large B-cell lymphoma |
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regulates stem cells renewal, maintenance, and differentiation into different cell lineages including neuron |
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stabilizes transcription by depositing repressive marks during development that persist into adulthood |
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negatively regulates Intracellular Ca2+ through suppression of PIP5K1C |
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acts as an oncogene in tumorigenesis of ovarian cancer with the possible mechanism to suppress the anti-oncogene CDKN1C |
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EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair |
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downregulates the important genes such as CDH1 and RUNX3 by increasing histone H3K27 trimethylation |
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an upstream regulator of anteroposterior prepattern at an early stage essential for cell survival and proximodistal segment elongation |
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required for pancreatic beta-cell expansion and metabolic changes from PDGFRA activation in beta-cells |
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triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine 27 of histone H3 (H3K27me2/3) |
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might be an oncogene with transforming activity that is linked to dysregulated cellular memory and transcriptional repression |
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is required to stabilize postnatal cardiac gene expression |
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modulates a feed-forward pathway that represses fetal gene expression and is reinforced by repression of SIX1 |
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UHRF1 along with EZH2 coordinate epigenetic silencing of tumour suppressor genes in prostate tumours |
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is involved in repressing gene expression through methylation of histone H3 on lysine 27 (H3K27) |
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mediates histone H3K27 trimethylation and is associated with gene silencing, coordinately expressed and function upstream of WHSC1, which mediates H3K36 dimethylation and is associated with active transcription |
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PRC2-EZH2 is important for the establishment of H3K27me3 in dividing cells, whereas PRC2-EZH1 is required for its maintenance in resting cells |
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critical redundancy of EZH1 and EZH2 in maintaining hepatic homeostasis and regeneration |
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EZH2-mediated BBC3 gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis |
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EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression |
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in neonatal heart regeneration, EZH1 was required, but EZH2 was dispensable |
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EZH2 is a critical regulator of genomic stability at stalled forks that couples histone modifications to nuclease recruitment |
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EZH2 has a dual function in tumorigenesis as an oncogene and tumor suppressor gene |