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FLASH GENE
Symbol EZH2 contributors: mct/shn - updated : 24-05-2017
HGNC name enhancer of zeste homolog 2 (Drosophila)
HGNC id 3527
ANIMAL & CELL MODELS
  • mice deficient for Ezh2 die at early stages of development by failing to complete gastrulation
  • conditional deletion of beta-cell Ezh2 in juvenile mice reduced H3 trimethylation at the Ink4a/Arf locus, leading to precocious increases of p16(INK4a) and p19(Arf), reduced beta-cell proliferation and mass, hypoinsulinemia, and mild diabetes (
  • hematopoietic-specific deletion of Ezh2 in mice induced heterogeneous hematopoietic malignancies