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FLASH GENE
Symbol EXOC6B contributors: mct - updated : 03-05-2014
HGNC name exocyst complex component 6B
HGNC id 17085
Location 2p13.2      Physical location : 72.406.444 - 73.053.177
Synonym name
  • SEC15-like 2 (S. cerevisiae
  • SEC15 homolog B (S. cerevisiae)
    • Synonym symbol(s) KIAA0919, SEC15B, SEC15L2
    DNA
    TYPE functioning gene
    STRUCTURE 650.06 kb     22 Exon(s)
    MAPPING cloned Y linked N status confirmed
    regionally located in the PARK3 region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2594 94 811 - 2008 18424204
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  moderately
    Nervousbrain    
     nerve   moderately
    Reproductivefemale systemplacenta  predominantly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Rsec15
    homolog to murine Exoc6b (99.1 pc)
    Homologene
    FAMILY
  • SEC15 family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text docking vesicles to the plasma membrane
    basic FUNCTION
  • involved in the docking of exocystic vesicles with fusion sites on the plasma membrane
  • acting as a regulator of polarized secretion
  • is a gene relevant for intellectual development and electrophysiological stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text
  • protein transport
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of brain exocyst complex, composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RALA binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS