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FLASH GENE
Symbol ESD contributors: - updated : 19-12-2005
HGNC name esterase D/formylglutathione hydrolase
HGNC id 3465
Location 13q14.1-q14.2      Physical location : 47.345.391 - 47.371.367
Synonym symbol(s) FGH
EC.number 3.1.1.1
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - D13S21 - D13S22 - D13S10 - ESD - RB1 - WND - D13S26 - qter
Text see RB1
Physical map
MGC5590 13q14.11 hypothetical protein MGC5590 LOC387923 13 similar to ribosome associated membrane protein 4 TSC22 13q14 transforming growth factor beta-stimulated protein TSC-22 LOC341659 13q14.11 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1 NUFIP1 13q14 nuclear fragile X mental retardation protein interacting protein 1 LSR7 13q13-q14 lipopolysaccharide specific response-7 protein GTF2F2 13q14 general transcription factor IIF, polypeptide 2, 30kDa KCTD4 13q14.12-q14.13 potassium channel tetramerisation domain containing 4 TPT1 13q14.1-q14.2 tumor protein, translationally-controlled 1 LOC338851 13q14.11 similar to Reticulocalbin 1 precursor LOC253512 13q14.11 hypothetical protein LOC253512 LOC390401 13 similar to peptidyl-Pro cis trans isomerase COG3 13q14.11 component of oligomeric golgi complex 3 FLJ32682 13q14.11 hypothetical protein FLJ32682 LOC390402 13 similar to Aldose reductase (AR) (Aldehyde reductase) NURIT 13q14.11 testis-specific leucine zipper protein nurit LOC283514 13q14.11 similar to seven in absentia 2 KIAA0853 13q14.11 KIAA0853 CPB2 13q14.11 carboxypeptidase B2 (plasma, carboxypeptidase U) LCP1 13q14.3 lymphocyte cytosolic protein 1 (L-plastin) LOC220416 13q14.11 similar to Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8) LOC390403 13 similar to hypothetical protein FLJ20457 C13orf18 13q14.11 chromosome 13 open reading frame 18 LOC81993 13q14-q21 COX17 pseudogene CHDC1 13q14.11 calponin homology (CH) domain containing 1 ESD 13q14.1-q14.2 esterase D/formylglutathione hydrolase HTR2A 13q14.3 5-hydroxytryptamine (serotonin) receptor 2A SUCLA2 13q12.2-q13.3 succinate-CoA ligase, ADP-forming, beta subunit NUDT15 13q14.12 nudix (nucleoside diphosphate linked moiety X)-type motif 15 VDRIP 13q14.12 vitamin D receptor interacting protein ITM2B 13q14.3 integral membrane protein 2B RB1 13q14.2 retinoblastoma 1 (including osteosarcoma) P2RY5 13q14 purinergic receptor P2Y, G-protein coupled, 5 CHC1L 13q14.3 chromosome condensation 1-like CYSLTR2 13q14.12-p21.1 cysteinyl leukotriene receptor 2 LOC338099 13q13 proteasome activator subunit 2 pseudogene KIAA0970 13q14.11 proteasome activator subunit 2 pseudogene RAD17P2 13q14.3 RAD17 homolog (S. pombe) pseudogene 2 COX7CP1 13q14-q21 cytochrome c oxidase subunit VIIc pseudogene 1 LOC387924 13 similar to hypothetical protein FLJ10826 GPR38 13q14-q21 G protein-coupled receptor 38 CDADC1 13q14.12 cytidine and dCMP deaminase domain containing 1 FLJ12577 13q14.12 hypothetical protein FLJ12577
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunelymph node   highly
 spleen   highly
Reproductivefemale systemovary  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY esterase D family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION may have a role in detoxification
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in ulcerative colitis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS