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FLASH GENE

Symbol

ESD

contributors: mct - updated : 10-10-2023

HGNC name	esterase D/formylglutathione hydrolase
HGNC id	3465

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q14.2      Physical location : 47.345.391 - 47.371.367
Synonym name	methylumbelliferyl-acetate deacetylase
	testicular tissue protein Li 66
Synonym symbol(s)	FGH, FLJ11763
EC.number	3.1.1.1/ 3.1.1.56 / 3.1.2.12

DNA

TYPE	functioning gene
STRUCTURE	26.44 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D13S21 - D13S22 - D13S10 - ESD - RB1 - WND - D13S26 - qter
Text	see RB1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001984 10 - 1121 NP_001975 - 282 - 1988 3164702

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Homo sapiens Lymphoid/Immune lymph node       highly Reproductive female system ovary     highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

esterase D family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	may have a role in detoxification
	enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication
	ESD served as a deacetylase to remove Thr89 acetylation of JAB1 and increased its activity
	is a nonspecific esterase that detoxifies formaldehyde

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

ESD/FKBP3/MTOR signaling pathway is involved in inhibiting tumor cell growth via regulating autophagy

a component

INTERACTION

DNA

RNA

small molecule

protein	ESD served as a deacetylase to remove Thr89 acetylation of COPS5 and increased its activity
	SPEG is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase D (ESD), CMYA5, and Fibronectin Type III and FSD2 in cardiac and skeletal muscle

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in ulcerative colitis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ESD activities are potential biomarkers for human lung adenocarcinoma, predicting the development of distant metastases and the presence of aggressive lung adenocarcinomas
Therapy target
	System Type Disorder Pubmed metabolism lipid cholesterol ESD is a potential drug target that promotes cholesterol metabolism cancer eye   serves as a potential marker for the prognosis of retinoblastoma.

ANIMAL & CELL MODELS