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FLASH GENE
Symbol ESD contributors: mct - updated : 10-10-2023
HGNC name esterase D/formylglutathione hydrolase
HGNC id 3465
DNA
TYPE functioning gene
STRUCTURE 26.44 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - D13S21 - D13S22 - D13S10 - ESD - RB1 - WND - D13S26 - qter
Text see RB1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1121 - 282 - 1988 3164702
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly Homo sapiens
Lymphoid/Immunelymph node   highly
Reproductivefemale systemovary  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY esterase D family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic,vesicle
basic FUNCTION
  • may have a role in detoxification
  • enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication
  • ESD served as a deacetylase to remove Thr89 acetylation of JAB1 and increased its activity
  • is a nonspecific esterase that detoxifies formaldehyde
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • ESD/FKBP3/MTOR signaling pathway is involved in inhibiting tumor cell growth via regulating autophagy
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ESD served as a deacetylase to remove Thr89 acetylation of COPS5 and increased its activity
  • SPEG is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase D (ESD), CMYA5, and Fibronectin Type III and FSD2 in cardiac and skeletal muscle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ESD activities are potential biomarkers for human lung adenocarcinoma, predicting the development of distant metastases and the presence of aggressive lung adenocarcinomas
  • Therapy target
    SystemTypeDisorderPubmed
    metabolismlipidcholesterol
    ESD is a potential drug target that promotes cholesterol metabolism
    cancereye 
    serves as a potential marker for the prognosis of retinoblastoma.
    ANIMAL & CELL MODELS