Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ERAL1 contributors: mct - updated : 28-05-2018
HGNC name Era G-protein-like 1 (E. coli)
HGNC id 3424
Corresponding disease
PRLTS6 Perrault Syndrome 6
Location 17q11.2      Physical location : 27.182.042 - 27.188.072
Synonym name
  • Era (E. coli G-protein homolog)-like 1
  • conserved ERA-like GTPase
  • GTPase, human homolog of E. coli essential cell cycle protein Era
  • GTP-binding protein era homolog
  • Synonym symbol(s) ERA, HERA-A, HERA-B, ERA, ERAL1A, CEGA, ERA-W, ERA-WA, ERAL1B, PRLTS6
    DNA
    TYPE functioning gene
    STRUCTURE 6.11 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product SDF2 17q11.2 stromal cell-derived factor 2 SUPT6H 17q11.2 suppressor of Ty 6 homolog (S. cerevisiae) MGC39650 17q11.2 hypothetical protein MGC39650 RAB34 17q11.1 RAB34, member RAS oncogene family RPL23A 17q11 ribosomal protein L23a LOC116238 17q11.2 hypothetical protein BC014072 NEK8 17q11.1 NIMA (never in mitosis gene a)- related kinase 8 TRAF4 17q11-q12 TNF receptor-associated factor 4 FLJ10700 17q11.2 hypothetical protein FLJ10700 ERAL1 17q11.2 Era G-protein-like 1 (E. coli) FLOT2 17q11.2-q12 flotillin 2 MGC23280 17q11.2 hypothetical protein MGC23280 PHF12 17q11.2 PHD finger protein 12 SEZ6 17q11.2 seizure related 6 homolog (mouse) LOC342659 17q11.2 similar to NADH-ubiquinone oxidoreductase 15 kDa subunit (Complex I-15 kDa) (CI-15 kDa) PIPOX 17q11.2 pipecolic acid oxidase TIAF1 17q11.1-q11.2 TGFB1-induced anti-apoptotic factor 1 LOC390783 17 hypothetical gene supported by U02680; NM_002822 CRYBA1 17q11.2-q12 crystallin, beta A1 182-FIP 17q11.2 82-kD FMRP Interacting Protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1856 48.2 437 - 2010 20604745
    9 - 1674 - 354 - 2010 20604745
    10 - 1920 - 436 - 2010 20604745
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestine   highly
     liver   predominantly
     stomach   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Urinarybladder   highly
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative N-terminal mitochondria targeting sequence of 59 amino acids
  • four GTP binding domains
  • a box a and a KH type-2 domain (RNA binding) at the C terminus
  • HOMOLOGY
    interspecies homolog to rattus Eral1 (78.4 pc)
    homolog to murine Eral1 (82.5 pc)
    intraspecies homolog to ERA
    Homologene
    FAMILY
  • era/mnmE GTP-binding protein family
  • Era subfamily
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • localized in mitochondrial matrix, in the mitochondrial matrix side of interspace and associated with mitoribosomal proteins
  • basic FUNCTION
  • acting as a putative tumor suppressor gene
  • playing an important role in the regulation of apoptotic signaling with its GTPase/GTP binding domain
  • plays an important role in the small ribosomal constitution, and is also involved in cell viability
  • required for proper assembly of mitochondrial ribosomal subunits and thus important for mitochondrial translation
  • role potential in the formation of functional ribosomal small subunits and might be involved in mitochondrial biogenesis and associated with the mitochondrial ribosome during the assembly, rRNA folding and RNA modification
  • play a crucial role in ribosome assembly
  • mitochondrial protein that associates with the small
  • 28S subunit of the mitoribosome
  • essential function of ERAL1 is as a 12S mt-rRNA chaperone
  • the timely removal of ERAL1 from the small ribosomal subunit is likely essential for the efficient maturation of the mitoribosome and a normal rate of mitochondrial translation
  • CELLULAR PROCESS cell cycle, division
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • GTP
  • protein
  • protein associated with TFAM
  • binds to the rRNA component of the small subunit
  • [12S mt (mitochondrial)-rRNA], with ERAL1-binding site to a 33 nucleotide section delineating the 3 prime terminal stem–loop region of 12S mt-rRNA
  • ERAL1 binds to the mitochondrial rRNA component of the ribosomal small subunit and is an important constituent of this subunit. p32, which is involved in mitochondrial translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRLTS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS