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FLASH GENE

Symbol

ERAL1

contributors: mct - updated : 28-05-2018

HGNC name	Era G-protein-like 1 (E. coli)
HGNC id	3424

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PRLTS6 Perrault Syndrome 6
Location	17q11.2      Physical location : 27.182.042 - 27.188.072
Synonym name	Era (E. coli G-protein homolog)-like 1
	conserved ERA-like GTPase
	GTPase, human homolog of E. coli essential cell cycle protein Era
	GTP-binding protein era homolog
Synonym symbol(s)	ERA, HERA-A, HERA-B, ERA, ERAL1A, CEGA, ERA-W, ERA-WA, ERAL1B, PRLTS6

DNA

TYPE	functioning gene
STRUCTURE	6.11 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005702 10 - 1856 NP_005693 48.2 437 - 2010 20604745 NM_001317986 9 - 1674 NP_001304915 - 354 - 2010 20604745 NM_001317985 10 - 1920 NP_001304914 - 436 - 2010 20604745

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine       highly   liver       predominantly   stomach       highly Reproductive female system uterus cervix   highly   female system ovary     highly Urinary bladder       highly   kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular       moderately

cell lineage
cell lines
fluid/secretion	highly in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative N-terminal mitochondria targeting sequence of 59 amino acids
	four GTP binding domains
	a box a and a KH type-2 domain (RNA binding) at the C terminus

HOMOLOGY

interspecies	homolog to rattus Eral1 (78.4 pc)
	homolog to murine Eral1 (82.5 pc)

intraspecies

homolog to ERA

Homologene

FAMILY	era/mnmE GTP-binding protein family
	Era subfamily

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
text	localized in mitochondrial matrix, in the mitochondrial matrix side of interspace and associated with mitoribosomal proteins

basic FUNCTION	acting as a putative tumor suppressor gene
	playing an important role in the regulation of apoptotic signaling with its GTPase/GTP binding domain
	plays an important role in the small ribosomal constitution, and is also involved in cell viability
	required for proper assembly of mitochondrial ribosomal subunits and thus important for mitochondrial translation
	role potential in the formation of functional ribosomal small subunits and might be involved in mitochondrial biogenesis and associated with the mitochondrial ribosome during the assembly, rRNA folding and RNA modification
	play a crucial role in ribosome assembly
	mitochondrial protein that associates with the small
	28S subunit of the mitoribosome
	essential function of ERAL1 is as a 12S mt-rRNA chaperone
	the timely removal of ERAL1 from the small ribosomal subunit is likely essential for the efficient maturation of the mitoribosome and a normal rate of mitochondrial translation

CELLULAR PROCESS	cell cycle, division
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule	nucleotide,
	GTP

protein	protein associated with TFAM
	binds to the rRNA component of the small subunit
	[12S mt (mitochondrial)-rRNA], with ERAL1-binding site to a 33 nucleotide section delineating the 3 prime terminal stem–loop region of 12S mt-rRNA
	ERAL1 binds to the mitochondrial rRNA component of the ribosomal small subunit and is an important constituent of this subunit. p32, which is involved in mitochondrial translation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PRLTS6

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS