Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ERAL1 contributors: mct - updated : 28-05-2018
HGNC name Era G-protein-like 1 (E. coli)
HGNC id 3424
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative N-terminal mitochondria targeting sequence of 59 amino acids
  • four GTP binding domains
  • a box a and a KH type-2 domain (RNA binding) at the C terminus
  • HOMOLOGY
    interspecies homolog to rattus Eral1 (78.4 pc)
    homolog to murine Eral1 (82.5 pc)
    intraspecies homolog to ERA
    Homologene
    FAMILY
  • era/mnmE GTP-binding protein family
  • Era subfamily
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • localized in mitochondrial matrix, in the mitochondrial matrix side of interspace and associated with mitoribosomal proteins
  • basic FUNCTION
  • acting as a putative tumor suppressor gene
  • playing an important role in the regulation of apoptotic signaling with its GTPase/GTP binding domain
  • plays an important role in the small ribosomal constitution, and is also involved in cell viability
  • required for proper assembly of mitochondrial ribosomal subunits and thus important for mitochondrial translation
  • role potential in the formation of functional ribosomal small subunits and might be involved in mitochondrial biogenesis and associated with the mitochondrial ribosome during the assembly, rRNA folding and RNA modification
  • play a crucial role in ribosome assembly
  • mitochondrial protein that associates with the small
  • 28S subunit of the mitoribosome
  • essential function of ERAL1 is as a 12S mt-rRNA chaperone
  • the timely removal of ERAL1 from the small ribosomal subunit is likely essential for the efficient maturation of the mitoribosome and a normal rate of mitochondrial translation
  • CELLULAR PROCESS cell cycle, division
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • GTP
  • protein
  • protein associated with TFAM
  • binds to the rRNA component of the small subunit
  • [12S mt (mitochondrial)-rRNA], with ERAL1-binding site to a 33 nucleotide section delineating the 3 prime terminal stem–loop region of 12S mt-rRNA
  • ERAL1 binds to the mitochondrial rRNA component of the ribosomal small subunit and is an important constituent of this subunit. p32, which is involved in mitochondrial translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRLTS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS