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FLASH GENE
Symbol EPSTI1 contributors: npt/mct - updated : 25-10-2016
HGNC name epithelial stromal interaction 1 (breast)
HGNC id 16465
Location 13q14.11      Physical location : 43.462.121 - 43.566.377
Synonym name
  • putative breast epithelial stromal interaction protein
  • cDNA FLJ78713, highly similar to Homo sapiens epithelial stromal
  • interaction 1
    Synonym symbol(s) BRESI1, MGC29634, hCG_2020353
    DNA
    TYPE functioning gene
    STRUCTURE 104.25 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SLC25A15 13q14 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 HCP34 13q14.11 cytochrome c, somatic pseudogene ELF1 13q13 E74-like factor 1 (ets domain transcription factor) WBP4 13q13.3 WW domain binding protein 4 (formin binding protein 21) KBTBD6 13q13.3 kelch repeat and BTB (POZ) domain containing 6 LOC390398 13 similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta) KBTBD7 13q13.3 kelch repeat and BTB (POZ) domain containing 7 MTRF1 13q14.1-q14.3 mitochondrial translational release factor 1 FLJ22054 13q13.3 hypothetical protein FLJ22054 LOC387922 13 similar to tubulin, beta 5 LOC390399 13 similar to olfactory receptor MOR145-1 OR7E37P 13q14.12 olfactory receptor, family 7, subfamily E, member 37 pseudogene RGC32 13q13.3 response gene to complement 32 KIAA0564 13q13.3 KIAA0564 protein DGKH 13q13.3 diacylglycerol kinase, eta MAPK6PS3 13q14.13 diacylglycerol kinase, eta LOC341651 13q13.3 similar to bA215B13.2 (fumarate hydratase (FH) pseudogene) AKAP11 13q14.3 a kinase (PRKA) anchor protein 11 FABP3P2 13q13-q14 fatty acid binding protein 3, pseudogene 2 TNFSF11 13q14 tumor necrosis factor (ligand) superfamily, member 11 FLJ40919 13q14.11 hypothetical protein FLJ40919 EPSTI1 13q13.3 epithelial stromal interaction 1 (breast) DNAJD1 13q14.1 DnaJ (Hsp40) homolog, subfamily D, member 1 FLJ10094 13q14.11 hypothetical protein FLJ10094 FLJ31846 13q14.11 hypothetical protein FLJ31846 FLJ38725 13q14.11 hypothetical protein FLJ38725 LOC283510 13q14.11 similar to Diacylglycerol kinase, zeta 104kDa MGC5590 13q14.11 hypothetical protein MGC5590 LOC387923 13 similar to ribosome associated membrane protein 4 TSC22 13q14 transforming growth factor beta-stimulated protein TSC-22 LOC341659 13q14.11 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3201 47 410 - 2002 11991720
    11 - 3136 35 307 - 2002 11991720
    - - 3227 - 318 - 2002 11991720
    - - 3135 - 180 - 2002 11991720
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Reproductivefemale systembreast   
     male systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • as a hitherto unappreciated regulator of tumor cell properties
  • PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLF8 promoted the EPSTI1 expression by directly acting on the EPSTI1 gene promoter
  • cell & other
    REGULATION
    induced by by epithelial-stromal interaction in human breast cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in invasive breast carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS