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FLASH GENE

Symbol

EPSTI1

contributors: npt/mct - updated : 25-10-2016

HGNC name	epithelial stromal interaction 1 (breast)
HGNC id	16465

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	104.25 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001002264 13 - 3201 NP_001002264 47 410 - 2002 11991720 NM_033255 11 - 3136 NP_150280 35 307 - 2002 11991720 NM_001330543 - - 3227 NP_001317472 - 318 - 2002 11991720 NM_001331228 - - 3135 NP_001318157 - 180 - 2002 11991720

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Reproductive female system breast         male system prostate       Respiratory respiratory tract larynx     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION

basic FUNCTION	as a hitherto unappreciated regulator of tumor cell properties
	PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	KLF8 promoted the EPSTI1 expression by directly acting on the EPSTI1 gene promoter

cell & other

REGULATION

induced by

by epithelial-stromal interaction in human breast cancer

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in invasive breast carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS