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Symbol EIF4G1 contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 4 gamma, 1
HGNC id 3296
Corresponding disease
PARK18 Parkinson disease 18
Location 3q27.1      Physical location : 184.032.282 - 184.053.145
Synonym symbol(s) p220, EIF4G, EIF4F, EIF-4G1, EIF4GI, PARK18
TYPE like-sequence
STRUCTURE 20.86 kb     33 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
FLJ12748 3q27.3 hypothetical protein FLJ12748 PSARL 3q27.3 presenilin associated, rhomboid-like LOC391598 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC391599 3 similar to cytochrome P450 2P1 ABCC5 3q27 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 LOC389179 3 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HTR3D 3q27.3 5-hydroxytryptamine receptor 3 subunit D HTR3C 3q27.3 5-hydroxytryptamine receptor 3 subunit C LOC389180 3 similar to 5-hydroxytryptamine receptor 3 subunit C HTR3E 3q27.3 5-hydroxytryptamine serotonin receptor 3E LOC285244 3q27.3 similar to Heat shock protein HSP 90-alpha (HSP 86) EIF2B5 3q27 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa DVL3 3q27 dishevelled, dsh homolog 3 (Drosophila) LOC389181 3 hypothetical gene supported by U14990; U14992; NM_001005 AP2M1 3q28 adaptor-related protein complex 2, mu 1 subunit ABCF3 3q25-q25.2 ATP-binding cassette, sub-family F (GCN20), member 3 LOC90113 3q27.3 hypothetical protein BC009862 ALG3 3q27.3 asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase) MGC2408 3q27.3 hypothetical protein MGC2408 CAM-KIIN 3q27.3 CaM-KII inhibitory protein ECE2 3q27q28 endothelin converting enzyme 2 PSMD2 3q27.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 EIF4G1 3q27-qter eukaryotic translation initiation factor 4 gamma, 1 MGC21688 3q27.3 hypothetical protein MGC21688 CLCN2 3q27-q28 chloride channel 2 POLR2H 3q28 polymerase (RNA) II (DNA directed) polypeptide H THPO 3q27-q28 thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) CHRD 3q27 chordin LOC285248 3q27.3 hypothetical LOC285248 LOC391600 3 similar to RIKEN cDNA 2310042E22 EPHB3 3q21-qter EphB3 MAGEF1 3q13 EphB3 LOC389182 3 LOC389182
TRANSCRIPTS type messenger
text three identified promoters, generating alternately spliced mRNAs, yielding a total of five EIF4G1 protein isoforms (PMID: 16982693)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 5636 - 1600 - 2006 16982693
33 - 5538 - 1599 - 2006 16982693
26 - 5050 - 1404 - 2006 16982693
30 - 5123 - 1435 - 2006 16982693
34 - 5559 - 1606 - 2006 16982693
33 - 5502 - 1606 - 2006 16982693
30 - 5300 - 1512 - 2006 16982693
34 - 5581 - 1559 - 2006 16982693
Type ubiquitous
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland highly
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
  • a RNA binding domain,a large middle alpha helical domain, RNA binding
  • the second binding site of EIF4G1 is important to understand the functional difference between EIF4G1 and EIF4BP1 for EIF4E translation
  • a C terminal eIF-5 domain maybe involved in interactions with eIF-2, and two atypical HEAT-repeat domains, supporting translational regulation by recruiting eIF4A, an RNA helicase, and MKNk1
    FAMILY eukaryotic translation initiation factor EIF4 family
    CATEGORY chaperone/stress , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • mRNA cap recognition, ATP-dependent unwinding of 5' terminal secondary structure (helicase activity) and recruitment of mRNA to ribosome
  • involved in the binding of mRNA cap structure to ribosome
  • increasing the poly (A)-binding protein (PABPx) RNA binding activity
  • plays a critical role in mRNA recruitment to the ribosomes
  • serves as a central adapter in cap-binding complex assembly
  • is potentially necessary for maintenance of neuronal viability
  • association of the translation factors polyadenylate-binding protein-1 (PABPC1) and EIF4G1 is essential for high-level expression of polyadenylated mRNAs
  • increased expression of EIF4G1 facilitates resistance to both apoptosis and autophagy following IR-mediated genotoxic DNA damage
  • EIF4G1 clearly has specific functions that do not overlap that of EIF4G2
  • plays a crucial role in translation initiation, serving as a scaffolding protein binding several other initiation factors, other proteins, and RNA
  • is related to tumorigenesis and tumor progression
  • EIF4G1 functions as an oncoprotein during non-small cell lung cancers (NSCLC) development
  • is required for cap-dependent mRNA translation, a process necessary for tumor growth and survival
  • EIF4G1, EIF4E, EIF4A1, and EIF4B, facilitate the recruitment of mRNA onto the preassembled 43S pre-initiation complex (PIC), thus leading to the formation of the 48S PIC
  • CELLULAR PROCESS protein, translation/synthesis
    a component
  • scaffold protein for the assembly of eIF4A, eIF4B, eIF4E, MKNK1, EIF4EBPs, PABPC1 to form the eukaryotic translation initiation complex eIF4F
    small molecule
  • binding to other EIFs
  • interacting with the poly (A)-binding protein (PABPx)
  • interacting with EIF4E3
  • NCBP1, NCBP2 independently interact with EIF4G1 (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • EIF4G1-PABPC1 interaction has been implicated in enhancing the formation of 48 S and 80 S initiation complexes and ribosome recycling through mRNA circularization
  • original role of NQO1 in the regulation of mRNA translation via the control of EIF4GI stability by the proteasome
  • MKNK1/MKNK2-EIF4G1 interaction is important for EIF4E phosphorylation
  • PRKCA activation elicits a cascade of orchestrated phosphorylation events that may modulate EIF4G1 structure and control interaction with the EIF4E kinase, MKNK1
  • EIF4E serves as a master switch that controls mRNA translation through the promotive binding to EIF4G1 and the regulative binding with the endogenous inhibitor EIF4EBP1
  • plays a unique role, not shared by its closest paralog MKNK1, in limiting protein translation through its negative effect on eIF4G Serıı&
  • 8304;&
    8312; phosphorylation and RPS6KB1 activation
  • EIF4G1 interacts with the RRM2 domain of PABPC1
  • EIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of AGO2 with the cap-binding complex
  • EIF4G1 protein binds to EIF3C, EIF3D, and EIF3D to promote mRNA recruitment to the ribosome
  • interaction of EIF4E with the initiation factor EIF4G1 recruits the 40S ribosomal particle to the 5prime end of mRNAs, facilitates scanning to the AUG start codon, and is crucial for eukaryotic translation of nearly all genes
  • low-frequency alterations such as EIF4G1 might participate in RET-associated tumorigenesis, possibly by regulating the activity of the RET pathway
  • interactions between VPS35, EIF4G1, and SNCA
  • EIF1-EIF4G1 cooperation involved in start codon selection
  • USP10 can directly interacts with EIF4G1, while acting as a negative regulator for EIF4G1-mediated functions
  • EIF4G1 plays a central role in translation initiation through its interactions with the cap-binding protein EIF4E
  • EIF4G2 and EIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors EIF3A and EIF4A1 and ribosomal proteins
  • cell & other
    Other calpain-mediated degradation of EIF4G1, is a cause of both persistent persistent protein synthesis inhibition and neuronal death
    regulation of EIF4GI stability by the proteasome may be prominent under oxidative stress
    corresponding disease(s) PARK18
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    squamous cell lung carcinoma
    tumoral     --low  
    depletion impairs cell proliferation, bioenergetics, and mitochondrial activity, thereby promoting autophagy
    tumoral     --over  
    in many breast cancers might act to specifically increase proliferation, prevent autophagy, and release tumor cells from control by nutrient sensing
    tumoral     --over  
    strongly increased in breast cancers
    tumoral     --over  
    in prostate carcinoma and is associated with tumor progression and metastasis
    Susceptibility to dementia with Lewy bodies
    Variant & Polymorphism other
  • variants in EIF4G1 can be associated with pathology that has a high likelihood of association with clinical features of dementia with Lewy bodies
  • Candidate gene
    Therapy target
    promising therapeutic target in lung cancer
    targeting EIF4G1 translation initiation factor affords an attractive therapeutic strategy in multiple myeloma
    may serve as a novel target for intervention in PCa and castration-resistant prostate cancer (CRPC)