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FLASH GENE
Symbol EIF4G1 contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 4 gamma, 1
HGNC id 3296
ASSOCIATED DISORDERS
corresponding disease(s) PARK18
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
squamous cell lung carcinoma
tumoral     --low  
depletion impairs cell proliferation, bioenergetics, and mitochondrial activity, thereby promoting autophagy
tumoral     --over  
in many breast cancers might act to specifically increase proliferation, prevent autophagy, and release tumor cells from control by nutrient sensing
tumoral     --over  
strongly increased in breast cancers
tumoral     --over  
in prostate carcinoma and is associated with tumor progression and metastasis
Susceptibility to dementia with Lewy bodies
Variant & Polymorphism other
  • variants in EIF4G1 can be associated with pathology that has a high likelihood of association with clinical features of dementia with Lewy bodies
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    promising therapeutic target in lung cancer
    cancerhemopathy 
    targeting EIF4G1 translation initiation factor affords an attractive therapeutic strategy in multiple myeloma
    cancerreproductiveprostate
    may serve as a novel target for intervention in PCa and castration-resistant prostate cancer (CRPC)
    ANIMAL & CELL MODELS