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FLASH GENE

Symbol

EIF4E2

contributors: mct - updated : 16-04-2013

HGNC name	eukaryotic translation initiation factor 4E-like 3
HGNC id	3293

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q37.1      Physical location : 233.415.356 - 233.433.919
Synonym name	elF4-like cap binding protein
Synonym symbol(s)	4EHP, IF4E, 4E-LP, EIF4EL3

DNA

TYPE	functioning gene
STRUCTURE	18.56 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D2S2158 - D2S396 - D2S172 - D2S206 - D2S331 - EIF4E2 - D2S336 - D2S2202 - D2S345 - D2S338 - D2S2338 - D2S2285 - D2S185 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004846 7 - 1014 NP_004837 - 245 - 2004 15153109

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Reproductive male system testis     predominantly Homo sapiens Adult Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

eukaryotic initiation factor 4E motif

HOMOLOGY

intraspecies

homolog to EIF4E

Homologene

FAMILY

EIF4E family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	recognizing the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis
	facilitating ribosome binding by inducing the unwinding of the mRNAs secondary structures
	mRNA 5prime cap structure-binding protein and acts as a translation suppressor by competing with EIF4E for binding to the cap structure
	like EIF4E it is able to bind the cap but it appears to play a different cellular role, possibly being involved in the fine-tuning of protein expression levels
	plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from EIF4E
	cannot compete with EIF4E for binding to the cap structure of most mRNAs

CELLULAR PROCESS	protein, translation/synthesis
	protein, translation regulation

PHYSIOLOGICAL PROCESS

text	cap binding protein

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding to 7-methylguanosine-containing mRNA cap

small molecule

protein	interaction with EIF4EBP1 is necessary for this observed impaired signaling to EIF4EBP1 and RPS6KB1
	modified by ISG15 and ISGylation of EIF4E2 may play an important role in cap structure-dependent translation control in immune responses
	PKNOX1- EIF4E2 interaction might bridge the 3prime UTR of HOXB4 mRNA to the 5prime cap structure
	GIGYF2 directly interacts with EIF4E2, and this interaction is required for stabilization of both proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS