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FLASH GENE
Symbol EIF4E2 contributors: mct - updated : 16-04-2013
HGNC name eukaryotic translation initiation factor 4E-like 3
HGNC id 3293
Location 2q37.1      Physical location : 233.415.356 - 233.433.919
Synonym name elF4-like cap binding protein
Synonym symbol(s) 4EHP, IF4E, 4E-LP, EIF4EL3
DNA
TYPE functioning gene
STRUCTURE 18.56 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - D2S2158 - D2S396 - D2S172 - D2S206 - D2S331 - EIF4E2 - D2S336 - D2S2202 - D2S345 - D2S338 - D2S2338 - D2S2285 - D2S185 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1014 - 245 - 2004 15153109
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemtestis  predominantly Homo sapiensAdult
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
eukaryotic initiation factor 4E motif
HOMOLOGY
intraspecies homolog to EIF4E
Homologene
FAMILY EIF4E family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,ribosome
basic FUNCTION
  • recognizing the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis
  • facilitating ribosome binding by inducing the unwinding of the mRNAs secondary structures
  • mRNA 5prime cap structure-binding protein and acts as a translation suppressor by competing with EIF4E for binding to the cap structure
  • like EIF4E it is able to bind the cap but it appears to play a different cellular role, possibly being involved in the fine-tuning of protein expression levels
  • plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from EIF4E
  • cannot compete with EIF4E for binding to the cap structure of most mRNAs
  • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text cap binding protein
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to 7-methylguanosine-containing mRNA cap
    small molecule
    protein
  • interaction with EIF4EBP1 is necessary for this observed impaired signaling to EIF4EBP1 and RPS6KB1
  • modified by ISG15 and ISGylation of EIF4E2 may play an important role in cap structure-dependent translation control in immune responses
  • PKNOX1- EIF4E2 interaction might bridge the 3prime UTR of HOXB4 mRNA to the 5prime cap structure
  • GIGYF2 directly interacts with EIF4E2, and this interaction is required for stabilization of both proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS