basic FUNCTION
| recognizing the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis |
|
facilitating ribosome binding by inducing the unwinding of the mRNAs secondary structures |
|
mRNA 5prime cap structure-binding protein and acts as a translation suppressor by competing with EIF4E for binding to the cap structure |
|
like EIF4E it is able to bind the cap but it appears to play a different cellular role, possibly being involved in the fine-tuning of protein expression levels |
|
plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from EIF4E |
|
cannot compete with EIF4E for binding to the cap structure of most mRNAs |
|
EIF4E, EIF4E2, and EIF4E3, are essential for translation initiation |
|
EIF4E2 functions are likely to be distinct from those of EIF4E, both in the cytoplasm and nucleus, and EIF4E2 shuttles through nuclei in a CRM1-dependent manner, but in an EIF4ENIF1-independent manner, also unlike EIF4E |
|
phenotypic expression of the cancer genome requires translation by the EIF4E2-directed hypoxic protein synthesis machinery |
|
EIF4E2-GIGYF2 are a cofactor in translational repression and mRNA decay by ZFP36 |
|
plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is required for formation of stress granules (SGs) |
|
may exhibit distinct functions under different stresses as it readily localizes to P-bodies during arsenite and heat stresses, whereas it is redirected to stress granules only upon heat shock |
|
|