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FLASH GENE
Symbol EIF4E2 contributors: mct - updated : 24-10-2016
HGNC name eukaryotic translation initiation factor 4E-like 3
HGNC id 3293
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemtestis  predominantly Homo sapiensAdult
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
eukaryotic initiation factor 4E motif
HOMOLOGY
intraspecies homolog to EIF4E
Homologene
FAMILY EIF4E family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,granule
intracellular,cytoplasm,cytosolic,ribosome
text
  • localization to stress granules under heat shock but not arsenite stress indicates its distinct function in cellular response to these stresses and points to the variable protein content of SGs as a consequence of different stress insults
  • basic FUNCTION
  • recognizing the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis
  • facilitating ribosome binding by inducing the unwinding of the mRNAs secondary structures
  • mRNA 5prime cap structure-binding protein and acts as a translation suppressor by competing with EIF4E for binding to the cap structure
  • like EIF4E it is able to bind the cap but it appears to play a different cellular role, possibly being involved in the fine-tuning of protein expression levels
  • plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from EIF4E
  • cannot compete with EIF4E for binding to the cap structure of most mRNAs
  • EIF4E, EIF4E2, and EIF4E3, are essential for translation initiation
  • EIF4E2 functions are likely to be distinct from those of EIF4E, both in the cytoplasm and nucleus, and EIF4E2 shuttles through nuclei in a CRM1-dependent manner, but in an EIF4ENIF1-independent manner, also unlike EIF4E
  • phenotypic expression of the cancer genome requires translation by the EIF4E2-directed hypoxic protein synthesis machinery
  • EIF4E2-GIGYF2 are a cofactor in translational repression and mRNA decay by ZFP36
  • plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is required for formation of stress granules (SGs)
  • may exhibit distinct functions under different stresses as it readily localizes to P-bodies during arsenite and heat stresses, whereas it is redirected to stress granules only upon heat shock
  • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text cap binding protein
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to 7-methylguanosine-containing mRNA cap
    small molecule
    protein
  • interaction with EIF4EBP1 is necessary for this observed impaired signaling to EIF4EBP1 and RPS6KB1
  • modified by ISG15 and ISGylation of EIF4E2 may play an important role in cap structure-dependent translation control in immune responses
  • PKNOX1- EIF4E2 interaction might bridge the 3prime UTR of HOXB4 mRNA to the 5prime cap structure
  • GIGYF2 directly interacts with EIF4E2, and this interaction is required for stabilization of both proteins
  • ZFP36 recruits eukaryotic initiation factor 4E2 (EIF4E2) to repress target mRNA translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS