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FLASH GENE
Symbol EIF2B3 contributors: - updated : 16-12-2006
HGNC name eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
HGNC id 3259
Corresponding disease
VWM5 leukoencephalopathy with vanishing white matter, type 5
Location 1p34.1      Physical location : 45.316.193 - 45.452.361
Synonym symbol(s) EIF-2B, EIF2Bgamma
DNA
TYPE functioning gene
STRUCTURE 135.00 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ATP6V0B 1p32.3 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' B4GALT2 1p34-p33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 MGC45441 1p34.1 hypothetical protein MGC45441 SLC6A9 1p33 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 LOC391034 1 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 FLJ40160 1p34.1 hypothetical protein FLJ40160 LOC128208 1p34.1 similar to dJ675G8.1 (novel zinc finger protein) DMAP1 1p34 DNA methyltransferase 1 associated protein 1 PRNPIP 1p32 prion protein interacting protein FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626 PTCH2 1p32.3-p32.1 patched homolog 2 (Drosophila) EIF2B3 1p34.1 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa LOC128192 1p34.1 similar to peptidyl-Pro cis trans isomerase FLJ21156 1p34.1 hypothetical protein FLJ21156 UROD 1p34 uroporphyrinogen decarboxylase ZSWIM5 1p34.1 zinc finger, SWIM domain containing 5 MGC15668 1p34.1 hypothetical protein MGC15668 MUTYH 1p34.3-p32.1 mutY homolog (E. coli) TOE1  target of EGR1, member 1 (nuclear) TESK2 1p32 testis-specific kinase 2 LOC126661 1p34.1 hypothetical protein LOC126661 DKFZP564I122 1p34.1 DKFZP564I122 protein PRDX1 1p34.1 peroxiredoxin 1 AKR1A1 1p33-p32 aldo-keto reductase family 1, member A1 (aldehyde reductase) NASP 1p34.1 nuclear autoantigenic sperm protein (histone-binding) FLJ33084 1p34.1 hypothetical protein FLJ33084 SP192 1p34.1 hypothetical protein SP192
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Nervousbrain    
Reproductivefemale systembreastmammary gland  
Respiratoryrespiratory tractlarynx  highly
Skeletonaxialskullfacemandible 
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
respiratorylungalveolar epitheliummacrophages 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus eif2b3
ortholog to murine Eif2b3
homolog to chimpanzee eif2b3
homolog to chicken eif2b3
Homologene
FAMILY EIF-2B gamma/epsilon subunits family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex of five different subunits, alpha, beta, gamma, delta and epsilon
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VWM5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Parkinson disease
    Susceptibility
    Variant & Polymorphism SNP influencing age at onset in Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS