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FLASH GENE
Symbol EIF2B3 contributors: - updated : 16-12-2006
HGNC name eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
HGNC id 3259
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus eif2b3
ortholog to murine Eif2b3
homolog to chimpanzee eif2b3
homolog to chicken eif2b3
Homologene
FAMILY EIF-2B gamma/epsilon subunits family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex of five different subunits, alpha, beta, gamma, delta and epsilon
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VWM5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Parkinson disease
    Susceptibility
    Variant & Polymorphism SNP influencing age at onset in Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS