| protein
| phosphorylating GJB1 actin cytoskeleton rearrangement resulting in membrane ruffling |
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interacting with RIPK1 (RIPK1 influences EGFR at the mRNA level by regulating the EGFR promoter)  |
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stimulating ER phosphorylation on tyrosine and promoting the association of a complex between EGFR, AR/ER, and the kinase Src |
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CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor |
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the autophoshorylated form interacts with PIK3C2B, maybe indirectly |
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key negative regulator of NOTCH1 gene expression in primary keratinocytes, intact epidermis and skin squamous cell carcinomas |
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interaction with ligands having differential effects of EGFR ligands on endocytic sorting of the receptor |
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USP18 overexpression elevated EGFR levels in a manner requiring the catalytic cysteine of USP18 |
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interacting with MMP9 (initiates cross-talk between CD44 and EGFR, which in turn activates downstream effectors for cell migration) |
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functional interaction between IQGAP1 and EGFR, suggesting that IQGAP1 modulates EGFR activation |
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LGALS3-dependent regulation of MUC1/EGFR functions may represent an interesting mechanism modulating the EGFR-stimulated cell growth of pancreatic cancer cells |
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USP18 is a potent regulator of EGFR protein expression |
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interacting with dynamin and clathrin that are necessary first steps for translocation of EGFR to the nucleus |
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SRC-dependent link between CHKA and EGFR, which contributes to the regulation of cell proliferation and tumorigenesis |
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cooperation between the EGF/EGFR and PTGES leads to a significant tumorigenic gain in epithelial cells |
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APPL1 function as a downstream effector of EGF-initiated signaling |
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FKBP1A forms an endogenous inhibitor of EGFR phosphorylation directly involved in the control of cellular EGFR activity |
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CDCP1 is a key regulator of EGF/EGFR-induced cell migration |
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STYK1 is likely colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR |
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enhanced the degradation of EGFR through accelerating its internalization in both EGF-independent and EGF-dependent manners |
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GRB2 mediates the interaction of TNK2 with EGFR through binding to the EBD and activates TNK2 by releasing the auto-inhibition |
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crucial role of cytosolic LGALS3 in controlling intracellular trafficking and cell surface expression of EGFR after EGF stimulation |
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EGFR activation also promotes RIN1 interaction with BIN1, a membrane bending protein |
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oncogenic KRAS upregulates endogenous EGFR expression and activation, the latter being dependent on the EGFR ligand sheddase, ADAM17 |
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inhibition of HDAC6 activity accelerated the trafficking of EGFR from early endosomes to late endosomes along the microtubules |
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EGFR, SFKs, and STAT3 can serve as substrates for the protein tyrosine phosphatase TCPTP (PTPN2) |
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role of ADAM17 during embryonic eyelid closure is to transactivate EGFR signaling |
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cross-talk between DSG3 and EGFR, and this cross-talk is regulated by MAPK |
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EGFR suppression of BECN1 may contribute to tumor progression in lung cancer |
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in cancer, simultaneous upregulation of EGFR and secretion of IL6 can cooperate to desensitize the cancer cells to the actions of negative regulators, especially SOCS3 |
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BTC binds and activates EGFR and ERBB4 homodimers |
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RASGRP1 creates a negative feedback loop that limits proliferative EGFR-SOS1-RAS signals in colorectal carcinoma cells |
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in ovarian cancer DSC3 and EGFR regulate each other and the activation of the AKT1 pathway, and AKT1 mediates FSH-dependent DSC3 expression |
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TMPRSS11E cleaved EGFR and downregulated the EGFR/AKT pathway to favor apoptosis |
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role of EGFR in modulating cellular iron homeostasis through redistribution of TFRC, which is essential for cancer development and progression |
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CHRM3-induced activation of MAPK14 might contribute to the maintenance of epithelial barrier function through down-regulation of TNF signalling and activation of EGFR |
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SEMA3C drives activation of multiple RTKs including EGFR, ERBB2, and MET in a cognate ligand-independent manner via PLXNB1 |
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RNF144A promotes EGFR ubiquitination, maintains EGFR protein, and prolongs EGF/EGFR signaling during EGF stimulation |
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MITF effectively suppresses EGFR and TGFA expression and therefore serves as link between NFE2L2 and EGFR |
